HKUST Researchers Uncover Key Transport Mechanisms in Cells, Shedding Light on Causes of Genetic Diseases
A Novel Proteomics Approach Identifies New Cargo Proteins and Essential Cellular Factors for Adaptor Complexes AP-1 And AP-4
Offering New Pathways for Understanding Hereditary Conditions
A research team led by Prof. GUO Yusong, Associate Professor of the Division of Life Science at The Hong Kong University of Science and Technology (HKUST) has made a significant breakthrough in understanding how cells manage the intricate internal transport of proteins, a process fundamental to life and implicated in several hereditary diseases. By employing an innovative vesicle proteomics platform, the team has systematically identified new cargo proteins and key accessory factors for two critical cellular transport complexes, AP-1 and AP-4. The findings, published in Proceedings of the National Academy of Sciences (PNAS), combine innovative vesicle reconstitution techniques with quantitative mass spectrometry-based proteomics to unveil a comprehensive map of previously unknown cargo proteins and regulatory factors.
https://hkust.edu.hk/news/hkust-researchers-uncover-key-transport-mechanisms-cells-shedding-light-causes-genetic