The course is designed for students with no science background. Using historical great breakthroughs in science and mathematics as examples, the course intends to inspire students to appreciate scientific approaches and develop a genuine appreciation towards human curiosity in the understanding of the world and the power of ingenuity observation to overcome ignorance. The course is composed of 4 modules covering topics in mathematics, physics, chemistry and biology. Examples of topics include geometry, quantum physics, forensic chemistry and theory of evolution. In addition, the course develops students' sense of enquiry thinking and foundation of scientific methods through various active learning processes.