This course builds on the fundamental knowledge of biosensors and bioinstrumentation. Lectures and hands-on laboratory experiments cover: (1) Basic concepts of biomedical signal analysis; (2) Measurements of bioelectrical, biomechanical and biochemical signals for medical diagnosis and clinical monitoring; (3) Principles of biosensors and biochips; (4) Simple design of new bioinstrumentation and biosensor to solve biomedical problems.