Synthetic biology, which echoes the assertion “What I cannot create, I do not understand” made by Richard Feynman, has been hailed as a revolution for modern science and technology. Unfledged as it is, the field, arising from the synergistic combination of chemistry, biology, engineering, data science, and information/control theory, has already shown great promise in addressing energy and health-related global challenges. This course aims to expose students with diverse backgrounds to this highly interdisciplinary field and furnish them with necessary guidance and ideas for taking on synthetic biology projects.