A scientific narrative of the evolution of the universe from the Big Bang all the way to the present (also known as Big History) will be introduced in this course. The course outlines how scientific methods can be used to understand the evolution of the physical, biological and social environment around us. It highlights the transdisciplinary nature of scientific knowledge, the importance of collaboration and self-critical claim testing, the accumulation of knowledge, the acceleration of technology all the way to Big Data and AI, and finally the social and environmental challenges posed by these changes. Climate change will be used as a detailed example of a complex environment and sustainability challenges in the 21st century. Students will be guided to appreciate how collaborations and system-thinking with integration and sharing of concepts across disciplines are required for addressing these challenges.