Projects per year
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where State Key Laboratory of Nervous System Disorders is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 14 Finished
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Investigating the genetic factors and associated mechanisms that modulate the risk effects of APOE-ε4 in Alzheimer’s disease
FU, K. Y. (PI), IP, N.Y.-Y. (CoI) & ZHOU, X. (CoI)
1/09/22 → 31/08/25
Project: Research
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Development Of A Blood-based Proteome Biomarker Panel For Alzheimer's Disease In Chinese
WONG, H. Y. (CoI), CHAN, L. T. A. (CoI), FU, K. Y. (CoI), IP, F. C. F. (CoI), IP, N.Y.-Y. (PI), KWOK, T. C. Y. (CoI) & MOK, V. C. T. (CoI)
Innovation and Technology Commission
1/06/21 → 31/05/24
Project: Research
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Medical Data Mining for Alzheimer's Disease, Dementia, and Cancer in the Hong Kong Population
FU, K. Y. (CoI), IP, F. C. F. (CoI), IP, N.Y.-Y. (PI), ZHONG, H. (CoI), FUNG, P. N. (CoI), KWOK, T. C. Y. (CoI) & ZHOU, X. (CoI)
Hospital Authority Data Collaboration Laboratory
7/04/21 → 31/03/22
Project: Research
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Integrative analysis of early risk prediction for Alzheimer’s disease and dementia in the Hong Kong population
FU, K. Y. (CoI), IP, F. C. F. (CoI), IP, N.Y.-Y. (PI), ZHONG, H. (CoI), MAK, T. W. T. (CoI), KWOK, T. C. Y. (CoI) & ZHOU, X. (CoI)
Hospital Authority Data Collaboration Laboratory
16/09/20 → 15/09/21
Project: Research
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Blood Transcriptomic Analysis of Parkinson's Disease in Han Chinese Population
CHEUNG, N. Y. (CoI), CHAN, G. H. (CoI), FU, K. Y. (PI), IP, F. C. F. (CoI), IP, N.Y.-Y. (CoI), CHAN, Y. C. P. (PI) & ZHOU, X. (CoI)
The Hong Kong Neurological Society
1/08/20 → 31/07/22
Project: Research
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Comprehensive Analysis Of Molecular, Structural And Functional Biomarkers For Alzheimer's Disease In The Chinese Population
CHEN, Y. (CoI), FU, K. Y. (CoI), IP, F. C. F. (CoI), IP, N.Y.-Y. (PI), GUO, Q. (CoI), LAI, K. O. (CoI), CHEUNG, T. (CoI), KWOK, T. C. Y. (CoI) & MOK, V. C. T. (CoI)
Innovation and Technology Commission
1/12/19 → 31/08/23
Project: Research
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Investigation of AD genetic risk factors in the Chinese population
IP, N.Y.-Y. (PI), ZETTERBERG, H. (CoI) & HARDY, J. (CoI)
Fidelity International Foundation
1/09/19 → 31/08/25
Project: Research
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Identification of epigenetic biomarkers for Alzheimer's disease in blood using epigenome-wide analysis
CHEN, Y. (CoI), FU, K. Y. (CoI), IP, F. C. F. (CoI), IP, N.Y.-Y. (PI), HARDY, J. (CoI), MOK, K. Y. B. (CoI), LAI, K. O. (CoI), CHEUNG, T. (CoI), KWOK, T. C. Y. (CoI) & MOK, V. C. T. (CoI)
Bio-Gene Technology Limited, Innovation and Technology Commission, Oracle Link Technology Ltd., Fong's Family Foundation
1/08/19 → 31/10/22
Project: Research
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Inhibition of EphA4 signaling for the prevention and treatment of neurological disorders
CHEN, Y. (CoI), FU, K. Y. (PI), LIU, K. (CoI), FOSTER, K. (CoI) & JEFSON, M. (CoI)
Innovation and Technology Commission, Orthogonal Neuroscience (HK) Limited
1/08/19 → 31/07/22
Project: Research
Research output
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A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis
LI, Y., HUANG, S., CHAN, L. S., LI, X., To, N. S., Zhao, X., JUNG, K., YANG, X., TSE, Y. C., Xu, N., Xia, Y., CHEUNG, T., QU, J. & MAK, H. Y., 7 May 2026, In: Nature Communications. 78 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
Active pixel power control for crosstalk-free All-optical neural interrogation
YAN, G., TIAN, G., FU, Y., HE, Y., SHE, Z., Chen, K. K. Y., SEMMELHACK, J. & QU, J., 11 Feb 2026, In: Nature Communications. 13 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
A dual-twisted molecular strategy achieves dramatic quantum-yield enhancement in NIR-II AIEgen for high-performance bioimaging
Yang, S., Guo, L., Ou, X., Yao, J., Zheng, J., Zheng, M., Jin, G., Zhou, S. & Tang, B. Z., Dec 2026, In: Biomaterials. 335, 10 p., 124404.Research output: Contribution to journal › Journal Article › peer-review
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Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner, I. H., Wagner, V. P., Moran-Losada, P., Shi, S. M., Golub, S. W., Hevler, J. F., Chen, K., Meese, B. T., Ghoochani, A., Pulido, E., Oh, H. S. H., Le Guen, Y., Lu, N., Wong, P. S., To, N. S., Garceau, D., Guo, Z., Luo, J., Bertozzi, C. R. & Lundberg, E. & 6 others, , 26 Feb 2026, In: Nature. 650, 8103, p. 930-941 43 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
A generative spike prediction model using behavioral reinforcement for re- establishing neural functional connectivity
WU, S., SONG, Z., ZHANG, X., HUANG, Y., CHEN, S., SHEN, X., TAN, J., LI, M., WANG, Z., CHEN, Y., LIU, K., Farina, D., Principe, J. C. & WANG, Y., Feb 2026, In: Nature Computational Science. 6, 2, p. 179-192 14 p.Research output: Contribution to journal › Journal Article › peer-review
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Aggregation-Induced-Emission Luminogens Functionalized MXene Nanosheets for Stimuli-Responsive Hydrogel in Pyroptosis-Mediated Choroidal Melanoma Therapy
Xu, Y., Wang, F., Liu, W., Lin, R., Liu, C., Zhao, Q., He, G., Yuan, G., Yin, W., Yu, F., Sun, J., Kwok, R. T. K., Lam, J. W. Y., Ren, L., Zhao, X., Yuan, J. & Tang, B. Z., 13 Mar 2026, In: Nano-Micro Letters. 18, 1, 22 p., 282.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
A "Jack-of-All-Trades" Phototheranostic System Enabled by Strategic Regulation of Ferroptosis and PANoptosis for Cancer Therapy
Lu, X., Xie, L., Yu, H., Zuo, Y., He, G., Wang, J., Yu, H., Yan, H., Kwok, R. T. K., Sun, J., Li, L., Ma, H., Lam, J. W. Y. & Tang, B. Z., 10 Feb 2026, In: ACS Nano. 20, 5, p. 4527-4541 15 p.Research output: Contribution to journal › Journal Article › peer-review
1 Link opens in a new tab Citation (Scopus) -
Alzheimer disease protection from the periphery
Wang, K. & Bu, G., Jun 2026, In: Nature Reviews Neurology. 22, 6, p. 335-336 2 p.Research output: Contribution to journal › Comment/debate
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A modernised fluorescent silver method for 3D brain histology using an AIE fluorogenic probe
Xie, S., Wong, A. Y. H., Kam, C., Hermanson, O., Ip, N. Y., Tang, B. Z. & Chen, S., Jun 2026, In: Science China Chemistry. 69, 6, p. 3145-3152 8 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)