Personal profile
Research interests
Biological Sciences - Neurodegenerative and age-related disorders
Biological Sciences - Neuroscience
Biological Sciences - Molecular and cellular neuroscience
Biological Sciences - Protein trafficking
Position Held
Related documents
Education/Academic qualification
PhD in Biochemistry, PhD, Virginia Polytechnic Institute and State University
1990
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Neuroimmune Mechanisms and Modulation in Alzheimer’s Disease
WU, A. R. (CoI), FU, K. Y. (CoPI), IP, N.Y.-Y. (CoPI), ZHU, B. D. (CoI), QU, J. (CoI), BU, G. (PI), LING, G. S. (CoI), CHOW, H. M. (CoI), KO, H. (CoPI), IP, Y. M. B. (CoI), WANG, J. (CoPI), LIU, K. (CoPI), LUI, K.O.-L. (CoPI), WANG, S. (CoPI) & MOK, V. C. T. (CoI)
RGC - Theme-based Research Scheme
1/01/26 → 31/12/30
Project: Research
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LRP1 and HSPG in tau pathological propagation and Alzheimer’s Disease
BU, G. (PI)
1/01/26 → 31/12/28
Project: Research
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Deciphering the role of TREM2 in microglial lysosome dynamics and Alzheimer's pathogenesis
CHEN, X. (PI) & BU, G. (PI)
National Natural Science Foundation of China (NSFC) / Research Grants Council (RGC)
1/01/26 → 31/12/29
Project: Research
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Regulation of lipid metabolism imbalance by APOE4 nanoantibody in the treatment of Alzheimer's disease
BU, G. (PI), LAM, Y. L. J. (Team member), XU, J. (CoI), WANG, J. (CoI), WANG, K. (CoI), TSE, K. L. (CoI), WANG , K. (Team member), LIU, X. (CoI) & YANG, X. (CoI)
1/07/25 → 30/06/26
Project: Research
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State Key Laboratory of Nervous System Disorders (SKLNSD)
WU, A. R. (CoI), WU, Z. (CoI), FU, K. Y. (CoPI), HUANG, P. (CoI), IP, N.Y.-Y. (PI), WONG, Y. H. (CoI), ZHU, B. D. (CoI), QU, J. (CoI), BU, G. (CoI), WANG, J. (CoI), CHEN, H. (CoI), LIU, K. (CoPI), YANG, C. (CoI), TANG, B. (CoI) & CHEUNG, T. (CoI)
Innovation and Technology Commission
1/07/25 → …
Project: Research
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Alzheimer disease protection from the periphery
Wang, K. & Bu, G., 14 Apr 2026, In: Nature Reviews Neurology.Research output: Contribution to journal › Comment/debate
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Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer’s disease
Zhu, Y., Lan, G., Li, A., Zhang, L., Jiang, M., Yang, J., Zhu, J., He, Z., Zhou, X., Li, M., Wang, Y., Sun, P., Cai, Y., Liu, Z., Wang, Y. J., Han, Y., Bu, G. & Guo, T., Aug 2026, In: Neurobiology of Aging. 164, p. 19-27 9 p.Research output: Contribution to journal › Journal Article › peer-review
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A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorder
Li, X., Hu, B., Wu, C., Wang, Z., Fan, H., Guan, X., Xie, S., Chen, D., Huang, X., Sun, H., Li, Y., Zhang, X., Bu, G., Wang, Z., Zhang, Y. W., Zhong, L., Zhang, Z. & Zheng, H., 17 Mar 2026, In: Cell Reports Medicine. 7, 3, 24 p., 102641.Research output: Contribution to journal › Journal Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
Raulin, A. C., Alnobani, A., Rodriguez-Martinez, P., Lee, E., Linares, C., Yslas, A. R., Li, M., Ren, Y., Doss, S. V., Roy, B., Kuchenbecker, L. A., Martens, Y. A., Liu, C. C., Bu, G. & Kanekiyo, T., 31 Mar 2026, In: Translational Psychiatry. 16, 1, 13 p., 224.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease
Lu, W., Kawatani, K., Ren, Y., Nambara, T., Jia, L., Jeevaratnam, S., Lee, E., Martinez, P. R., Izhar, T., Wang, N., Raulin, A. C., Wszolek, Z. K., Bu, G., Kanekiyo, T. & Li, Y., 7 Feb 2026, In: Alzheimer's Research and Therapy. 18, 1, 17 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access
Activities
- 3 Editorial work
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Neuron (Journal)
BU, G. (Editorial Board Member)
1 Jan 2020 → …Activity: Publication peer-review and editorial work › Editorial work
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Science Advances (Journal)
BU, G. (Associate Editor)
1 Jan 2018 → …Activity: Publication peer-review and editorial work › Editorial work
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Molecular Neurodegeneration (Journal)
BU, G. (Chief Editor)
1 Jan 2016 → …Activity: Publication peer-review and editorial work › Editorial work