Projects per year
Personal profile
Research interests
Biological Sciences - Aging
Biological Sciences - Neurodegenerative and age-related disorders
Biological Sciences - Neuroscience
Biological Sciences - Molecular and cellular neuroscience
Biological Sciences - Protein trafficking
Biological Sciences - Neurodegenerative and age-related disorders
Biological Sciences - Neuroscience
Biological Sciences - Molecular and cellular neuroscience
Biological Sciences - Protein trafficking
Position Held
Co-Director of Brain and Intelligence Research Institute
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Related documents
Education/Academic qualification
PhD in Biochemistry, PhD, Virginia Polytechnic Institute and State University
1990
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Deciphering the role of TREM2 in microglial lysosome dynamics and Alzheimer's pathogenesis
CHEN, X. (PI) & BU, G. (PI)
1/01/26 → 31/12/29
Project: Research
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LRP1 and HSPG in tau pathological propagation and Alzheimer’s Disease
BU, G. (PI)
1/01/26 → 31/12/28
Project: Research
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Regulation of lipid metabolism imbalance by APOE4 nanoantibody in the treatment of Alzheimer's disease
BU, G. (PI), LAM, Y. L. J. (Team member), XU, J. (CoI), WANG, J. (CoI), WANG, K. (CoI), TSE, K. L. (CoI), WANG , K. (Team member), LIU, X. (CoI) & YANG, X. (CoI)
1/07/25 → 30/06/26
Project: Research
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ApoE in choroid plexus function and related Alzheimer's disease pathogenesis
BU, G. (PI)
1/03/25 → 28/02/27
Project: Research
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Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice
Ma, X., Prokopenko, D., Wang, N., Aikawa, T., Choi, Y., Zhang, C., Lei, D., Ren, Y., Kawatani, K., Starling, S. C., Perkerson, R. B., Roy, B., Quintero, A. C., Parsons, T. M., Pan, Y., Li, Z., Wang, M., Bao, H., Han, X. & Bu, G. & 2 others, , Mar 2025, In: Neurobiology of Disease. 206, 106813.Research output: Contribution to journal › Journal Article › peer-review
Open Access3 Citations (Scopus) -
Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease
Lu, W., Shue, F., Kurti, A., Jeevaratnam, S., Macyczko, J. R., Roy, B., Izhar, T., Wang, N., Bu, G., Kanekiyo, T. & Li, Y., Jan 2025, In: Neurobiology of Aging. 145, p. 13-23 11 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access2 Citations (Scopus) -
A p16 pathway to prevention: Senescence as a driver of tau-mediated neurodegeneration
Lam, J. Y. L., Wang, K. & Bu, G., 23 Jul 2025, In: Neuron. 113, 14, p. 2215-2217 3 p.Research output: Contribution to journal › Comment/debate
1 Citation (Scopus) -
APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease
Li, Z., Martens, Y. A., Ren, Y., Jin, Y., Sekiya, H., Doss, S. V., Kouri, N., Castanedes-Casey, M., Christensen, T. A., Miller Nevalainen, L. B., Takegami, N., Chen, K., Liu, C. C., Soto-Beasley, A., Boon, B. D. C., Labuzan, S. A., Ikezu, T. C., Chen, Y., Bartkowiak, A. D. & Xhafkollari, G. & 10 others, , 7 May 2025, In: Neuron. 113, 9, p. 1380-1397.e7Research output: Contribution to journal › Journal Article › peer-review
Open Access9 Citations (Scopus) -
APOE genotype influences on the brain metabolome of aging mice - role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype
Alzheimer’s Disease Metabolomics Consortium, 2 Sept 2025, In: Molecular Neurodegeneration. 20, 1, p. 97 1 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access
Activities
- 3 Editorial work
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Neuron (Journal)
BU, G. (Editorial Board Member)
1 Jan 2020 → …Activity: Publication peer-review and editorial work › Editorial work
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Science Advances (Journal)
BU, G. (Associate Editor)
1 Jan 2018 → …Activity: Publication peer-review and editorial work › Editorial work
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Molecular Neurodegeneration (Journal)
BU, G. (Chief Editor)
1 Jan 2016 → …Activity: Publication peer-review and editorial work › Editorial work