Projects per year
Personal profile
Research interests
Biological Sciences - Neurobiology and neurosciences
Biological Sciences - Neurodegenerative and age-related disorders
Biotechnology - Gene therapy
Biological Sciences - Molecular mechanisms of neurodegeneration
Biological Sciences - Neurodegenerative and age-related disorders
Biotechnology - Gene therapy
Biological Sciences - Molecular mechanisms of neurodegeneration
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Related documents
Education/Academic qualification
PhD in Life Science, PhD, The Hong Kong University of Science and Technology
2022
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Collaborations and top research areas from the last five years
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Projects
- 1 Active
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Investigating the effects and underlying mechanisms of Aβ reduction on Alzheimer’s pathologies in a transgenic mouse model
FU, K. Y. (CoI), IP, N.Y.-Y. (CoI) & DUAN, Y. (PI)
1/07/24 → 30/06/27
Project: Research
Research output
- 6 Journal Article
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The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in the mouse visual cortex
Jenks, K. R., Cai, Y., Nayan, M. E., Tsimring, K., Li, K., Zepeda, J. C., Heller, G. R., Delepine, C., Shih, J., Yuan, S., Zhu, Y., Wang, Y., Duan, Y., Fu, A. K. Y., Ku, T., Yun, D. H., Chung, K., Mellios, N., Sur, M. & Ip, J. P. K., 19 Sept 2025, In: iScience. 28, 9, 113421.Research output: Contribution to journal › Journal Article › peer-review
Open Access1 Citation (Scopus) -
Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury
Chen, W., Wu, J., Yang, C., Li, S., Liu, Z., An, Y., Wang, X., Cao, J., Xu, J., Duan, Y., Yuan, X., Zhang, X., Zhou, Y., Ip, J. P. K., Fu, A. K. Y., Ip, N. Y., Yao, Z. & Liu, K., 24 Sept 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 39, e2404395121.Research output: Contribution to journal › Journal Article › peer-review
7 Citations (Scopus) -
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
Goertsen, D., Flytzanis, N. C., Goeden, N., Chuapoco, M. R., Cummins, A., Chen, Y., Fan, Y., Zhang, Q., Sharma, J., Duan, Y., Wang, L., Feng, G., Chen, Y., Ip, N. Y., Pickel, J. & Gradinaru, V., Jan 2022, In: Nature Neuroscience. 25, 1, p. 106-115 10 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access276 Citations (Scopus) -
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Duan, Y., Ye, T., Qu, Z., Chen, Y., Miranda, A., Zhou, X., Lok, K. C., Chen, Y., Fu, A. K. Y., Gradinaru, V. & Ip, N. Y., Feb 2022, In: Nature Biomedical Engineering. 6, 2, p. 168-180 13 p.Research output: Contribution to journal › Journal Article › peer-review
44 Citations (Scopus) -
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
Ye, T., Duan, Y., Tsang, H. W. S., Xu, H., Chen, Y., Cao, H., Chen, Y., Fu, A. K. Y. & Ip, N. Y., Dec 2021, In: Communications Biology. 4, 1, 195.Research output: Contribution to journal › Journal Article › peer-review
Open Access12 Citations (Scopus)
Awards
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Gold Medal with Congratulations of the Jury and Honorable Mention Prize of the Chinese Delegation
DUAN, Y. (Recipient), Apr 2024
Prize: Other Research Award and Prize