Projects per year
Personal profile
Research interests
Biological Sciences - Deoxyribonucleic acid (DNA) replication
Biological Sciences - Epigenetics
Biological Sciences - Chromatin structure
Biological Sciences - Structural biology
Biotechnology - Imaging techniques
Biotechnology - Electron microscopy
Biological Sciences - Epigenetics
Biological Sciences - Chromatin structure
Biological Sciences - Structural biology
Biotechnology - Imaging techniques
Biotechnology - Electron microscopy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD in Biochemistry, PhD, The Hong Kong University of Science and Technology
2010
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Molecular Mechanisms of Helicase Activation in eukaryotes
ZHAI, Y. (PI)
1/10/25 → 30/09/28
Project: Research
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Mechanistic Study of the Parental Histone Recycling at Replication Forks
GAO, N. (PI), LI, X. (CoPI) & ZHAI, Y. (PI)
1/01/25 → 31/12/27
Project: Research
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From Structural to Genomic Biology: A Multi-scale Approach Tightly Integrating Structural Biology and Novel Genomics Platform to Quantitatively Analyze the Transcription and its Regulation of SARS-CoV-2 Viral RNA Polymerase
ZHAI, Y. (CoPI)
RGC - Collaborative Research Fund
1/01/25 → 29/12/26
Project: Research
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Chromatin replication and its regulation
ZHAI, Y. (PI)
National Natural Science Foundation of China
1/01/25 → 31/12/29
Project: Research
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Helicase loading mechanism modulated by an intrinsically disordered region of Orc2 in yeast
ZHAI, Y. (PI)
1/01/25 → 31/08/26
Project: Research
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ANKLE1 processes chromatin bridges by cleaving mechanically stressed DNA
Jiang, H., He, F., Kong, N., Long, J., Poon, Y. C., Punatar, R. S., Xu, Z., Zhai, Y., West, S. C., Efremov, A. K. & Chan, Y. W., 8 Dec 2025, In: Nature Communications. 16, 1, 10855.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
DNA bending mediated by ORC is essential for replication licensing in budding yeast
Lam, W. H., Yu, D., Zhang, Q., Lin, Y., Li, N., Li, J., Wu, Y., Zhang, Y., Gao, N., Tye, B. K., Zhai, Y. & Dang, S., 8 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 14, e2502277122.Research output: Contribution to journal › Journal Article › peer-review
1 Citation (Scopus) -
H2B.W2, a spermatocyte-specific histone variant, disrupts nucleosome stability, and reduces chromatin compaction
Nguyen, A. T. T., Ding, D., Bai, X., Pang, M. Y. H., Deng, M., Liu, Y., Jin, T., Xu, Z., Zhang, Y., Zhai, Y., Yan, Y. & Ishibashi, T., 9 Sept 2025, In: Nucleic Acids Research. 53, 16, gkaf825.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
MCM5 UFMylation regulates replication origin firing and fork progression
Li, Z., Wu, X., Liu, L., Rao, S., Liao, Y., Liu, M., Peng, B., Zhang, Q., Xia, Y., Zhai, Y., Takeda, S. & Xu, X., 3 Nov 2025, In: EMBO Journal. 44, 21, p. 6019-6050 32 p.Research output: Contribution to journal › Journal Article › peer-review
Open Access -
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets
Luo, J., Lam, W. H., Yu, D., Chao, V. C., Zopfi, M. N., Khoo, C. J., Zhao, C., Yan, S., Liu, Z., Li, X. D., Zheng, C., Zhai, Y. & Ti, S. C., Feb 2025, In: Nature Structural and Molecular Biology. 32, 2, p. 358-368 11 p., 17477.Research output: Contribution to journal › Journal Article › peer-review
6 Citations (Scopus)
Press/Media
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13 HKUST Research Projects Secure Top Funding from RGC Collaborative Research Fund and Research Impact Fund
WANG, D., WANG, S., CHEN, S., TSANG, C. W., ZHAI, Y., ZHANG, F., LI, M., MENG, Z., WANG, G., YANG, Y., LU, H., LI, X. & CHENG, K.-T. T.
7/01/26
1 item of Media coverage
Press/Media