Projects per year
Personal profile
Research interests
Biological Sciences - Stem cell biology
Biological Sciences - Cell signaling
Biological Sciences - Muscle stem cells
Biological Sciences - Transcriptional regulation
Biological Sciences - Muscle differentiation and regeneration
Biological Sciences - Cell signaling
Biological Sciences - Muscle stem cells
Biological Sciences - Transcriptional regulation
Biological Sciences - Muscle differentiation and regeneration
Position Held
Director of Center for Stem Cell Research
Associate Director of Biotechnology Research Institute
Associate Director of Biotechnology Research Institute
Related documents
Education/Academic qualification
PhD in Biochemistry, PhD, The University of Western Ontario
1995
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 12 Responsible Consumption and Production
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Dive into the research topics where Zhenguo WU is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mechanistic studies of defective quiescence maintenance of adult muscle stem cells in type 2 diabetes
WU, Z. (PI)
1/09/26 → 31/08/29
Project: Research
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Investigation of the role of TruB1 in adult muscle satellite cells
WU, Z. (CoI), HAN, L. (PI) & ZHANG, L. (CoI)
1/07/26 → 30/06/29
Project: Research
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State Key Laboratory of Nervous System Disorders (SKLNSD)
WU, A. R. (CoI), WU, Z. (CoI), FU, K. Y. (CoPI), HUANG, P. (CoI), IP, N.Y.-Y. (PI), WONG, Y. H. (CoI), ZHU, B. D. (CoI), QU, J. (CoI), BU, G. (CoI), WANG, J. (CoI), CHEN, H. (CoI), LIU, K. (CoPI), YANG, C. (CoI), TANG, B. (CoI) & CHEUNG, T. (CoI)
Innovation and Technology Commission
1/07/25 → …
Project: Research
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Developing Innovative Therapeutic Candidates for Fibrosis-related Diseases by Targeting Novel Anti-fibrotic Signaling of tRNA-synthetases
WU, Z. (PI), NANGLE, L. (PI) & TIAN, H. (CoI)
Innovation and Technology Commission, Pangu BioPharma Ltd.
1/11/24 → 30/06/27
Project: Research
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Investigation of the role of Gcfc2 in regulating adult muscle stem cells
WU, Z. (PI)
1/09/24 → 31/08/27
Project: Research
Research output
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A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F
Tian, H., Fung, C. P., Burman, L., Chong, Y. E., Liu, C., Geng, Y., Yang, L., Chow, M. W., Zhang, Y., Ho, K. W. H., Zhu, G., Wu, Z., Yang, X. L., Xu, Z. & Nangle, L. A., Feb 2026, In: Journal of Biological Chemistry. 302, 2, 111056.Research output: Contribution to journal › Journal Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Native postsynaptic density is a functional condensate formed via phase separation
CHEN, S., Cai, Q., Peng, H., YANG, Y., WU, Z. & ZHANG, M., 27 Jan 2026, In: Cell Reports. 45, 1, 116723.Research output: Contribution to journal › Journal Article › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells
Han, L., Qiu, Y., He, L., Gao, C., Zhou, N., Fu, X., Xu, J., Lin, L., Wang, H., Biswal, S. & Wu, Z., 25 Nov 2025, In: Nature Communications. 16, 17 p., 10505.Research output: Contribution to journal › Journal Article › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation
Chen, X., Li, Y., Xu, J., Cui, Y., Wu, Q., Yin, H., Li, Y., Gao, C., Jiang, L., Wang, H., Wen, Z., Yao, Z. & Wu, Z., Jun 2024, In: eLife. v. 12, RP87434.Research output: Contribution to journal › Journal Article › peer-review
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Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration
He, Y., Heng, Y., Qin, Z., Wei, X., Wu, Z. & Qu, J., 2023, In: Science Advances. 9, 42, eadi1891.Research output: Contribution to journal › Journal Article › peer-review
Open Access19 Link opens in a new tab Citations (Scopus)
Activities
- 3 Invited
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Mechanistic insights into a role of Pax7 in quiescence maintenance in adult muscle stem cells
WU, Z. (Invited speaker)
31 Oct 2025Activity: Talk or presentation › Invited
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Non-canonical roles of the Keap1/Nrf2 axis in regulating quiescence and early activation in adult muscle stem cells
WU, Z. (Invited speaker)
7 Oct 2025Activity: Talk or presentation › Invited
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NON-canonical roles of the Keap1/Nrf2 axis in regulating quiescence and early activation in adult muscle stem cells
WU, Z. (Invited speaker)
4 Oct 2025Activity: Talk or presentation › Invited
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