A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

Chung Wai Chan; Hoi Ling Ada Siu; Zumeng Xia; Kam Ming Ko; Hoi Yan Leung

doi:10.4236/cm.2023.144012

A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

Chung Wai Chan, Hoi Ling Ada Siu, Zumeng Xia, Kam Ming Ko^*, Hoi Yan Leung

^*Corresponding author for this work

Division of Life Science

Research output: Contribution to journal › Journal Article › peer-review

Abstract

The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.

Original language	English
Pages (from-to)	242-254
Journal	Chinese Medicine
Volume	14
DOIs	https://doi.org/10.4236/cm.2023.144012
Publication status	Published - Feb 2023

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title = "A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats",

abstract = "The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76\%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.",

author = "Chan, \{Chung Wai\} and Siu, \{Hoi Ling Ada\} and Zumeng Xia and Ko, \{Kam Ming\} and Leung, \{Hoi Yan\}",

year = "2023",

month = feb,

doi = "10.4236/cm.2023.144012",

language = "English",

volume = "14",

pages = "242--254",

journal = "Chinese Medicine",

issn = "2151-1918",

publisher = "Scientific Research Publishing",

}

TY - JOUR

T1 - A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

AU - Chan, Chung Wai

AU - Siu, Hoi Ling Ada

AU - Xia, Zumeng

AU - Ko, Kam Ming

AU - Leung, Hoi Yan

PY - 2023/2

Y1 - 2023/2

N2 - The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.

AB - The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.

UR - https://openalex.org/W4388933392

U2 - 10.4236/cm.2023.144012

DO - 10.4236/cm.2023.144012

M3 - Journal Article

SN - 2151-1918

VL - 14

SP - 242

EP - 254

JO - Chinese Medicine

JF - Chinese Medicine

ER -

A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

Abstract

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