A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol

Yijin Wang; Chen Xu; Jiong Li; I. Ming Hsing; Mansun Chan

doi:10.1016/j.sse.2005.09.015

A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol

Yijin Wang^*, Chen Xu, Jiong Li, I. Ming Hsing, Mansun Chan

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

9 Citations (Scopus)

Abstract

A DNA micro-array (DMA) for DNA detection is reported. The DMA combines a standard CMOS active pixel image sensor with a DNA detection protocol utilizing the binding of DNA targets and probes functionalized with gold nano-particles that can modify the opaqueness at the detection site. The DMA has been fabricated using a 0.5 μm CMOS process together with on-chip timing control and correlated double sampling. Experimental results show that the system can detect DNA samples with extremely low concentration down to 10 pM using ordinary light source.

Original language	English
Pages (from-to)	1933-1936
Number of pages	4
Journal	Solid-State Electronics
Volume	49
Issue number	12
DOIs	https://doi.org/10.1016/j.sse.2005.09.015
Publication status	Published - Dec 2005

Keywords

Adjustable dynamic range
CMOS compatible
High sensitivity

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10.1016/j.sse.2005.09.015

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title = "A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol",

abstract = "A DNA micro-array (DMA) for DNA detection is reported. The DMA combines a standard CMOS active pixel image sensor with a DNA detection protocol utilizing the binding of DNA targets and probes functionalized with gold nano-particles that can modify the opaqueness at the detection site. The DMA has been fabricated using a 0.5 μm CMOS process together with on-chip timing control and correlated double sampling. Experimental results show that the system can detect DNA samples with extremely low concentration down to 10 pM using ordinary light source.",

keywords = "Adjustable dynamic range, CMOS compatible, High sensitivity",

author = "Yijin Wang and Chen Xu and Jiong Li and Hsing, \{I. Ming\} and Mansun Chan",

year = "2005",

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doi = "10.1016/j.sse.2005.09.015",

language = "English",

volume = "49",

pages = "1933--1936",

journal = "Solid-State Electronics",

issn = "0038-1101",

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T1 - A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol

AU - Wang, Yijin

AU - Xu, Chen

AU - Li, Jiong

AU - Hsing, I. Ming

AU - Chan, Mansun

PY - 2005/12

Y1 - 2005/12

N2 - A DNA micro-array (DMA) for DNA detection is reported. The DMA combines a standard CMOS active pixel image sensor with a DNA detection protocol utilizing the binding of DNA targets and probes functionalized with gold nano-particles that can modify the opaqueness at the detection site. The DMA has been fabricated using a 0.5 μm CMOS process together with on-chip timing control and correlated double sampling. Experimental results show that the system can detect DNA samples with extremely low concentration down to 10 pM using ordinary light source.

AB - A DNA micro-array (DMA) for DNA detection is reported. The DMA combines a standard CMOS active pixel image sensor with a DNA detection protocol utilizing the binding of DNA targets and probes functionalized with gold nano-particles that can modify the opaqueness at the detection site. The DMA has been fabricated using a 0.5 μm CMOS process together with on-chip timing control and correlated double sampling. Experimental results show that the system can detect DNA samples with extremely low concentration down to 10 pM using ordinary light source.

KW - Adjustable dynamic range

KW - CMOS compatible

KW - High sensitivity

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000234233800009

UR - https://openalex.org/W1993580509

UR - https://www.scopus.com/pages/publications/28044437553

U2 - 10.1016/j.sse.2005.09.015

DO - 10.1016/j.sse.2005.09.015

M3 - Journal Article

SN - 0038-1101

VL - 49

SP - 1933

EP - 1936

JO - Solid-State Electronics

JF - Solid-State Electronics

IS - 12

ER -

A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol

Abstract

Keywords

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