TY - GEN
T1 - A mechanism to explain zero-delay bilateral seizure synchronization
AU - Wang, Y.
AU - Toprani, S.
AU - Tang, D.
AU - Durand, D. M.
PY - 2011
Y1 - 2011
N2 - Synchronization in bilateral CA3 regions via fimbria-fornix-hippocampal commissures system (FFHC) in rodent hippocampus has revealed that bilateral seizures can sometimes be synchronized with very small delays ( 1ms). This observed small time delay at the start of afterdischarges between the left and right CA3 regions is unexpected given the propagation time across the hemispheres ( 6ms). The possibility of a common source was first eliminated by in-vitro brain slices experiments. We then tested the hypothesis that, in the presence of noise, synchronization can take place before the seizure activity is sufficient large to be detected generating an apparent zero-delay between the two sides. This hypothesis was tested with computer simulation with a network of interconnected hippocampal neurons. These results provide an explanation for this aberrant simultaneous seizure detection and indicate the importance of noise in the interpretation of the timing of neuronal events.
AB - Synchronization in bilateral CA3 regions via fimbria-fornix-hippocampal commissures system (FFHC) in rodent hippocampus has revealed that bilateral seizures can sometimes be synchronized with very small delays ( 1ms). This observed small time delay at the start of afterdischarges between the left and right CA3 regions is unexpected given the propagation time across the hemispheres ( 6ms). The possibility of a common source was first eliminated by in-vitro brain slices experiments. We then tested the hypothesis that, in the presence of noise, synchronization can take place before the seizure activity is sufficient large to be detected generating an apparent zero-delay between the two sides. This hypothesis was tested with computer simulation with a network of interconnected hippocampal neurons. These results provide an explanation for this aberrant simultaneous seizure detection and indicate the importance of noise in the interpretation of the timing of neuronal events.
UR - https://openalex.org/W1998621520
UR - https://www.scopus.com/pages/publications/84864586875
U2 - 10.1109/IEMBS.2011.6091699
DO - 10.1109/IEMBS.2011.6091699
M3 - Conference Paper published in a book
C2 - 22256021
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 7286
EP - 7289
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -