A PGC-1 tale: Healthier intestinal stem cells, longer life

Yi Zhou, Tinglin Lu, Ting Xie*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

5 Citations (Scopus)

Abstract

PGC-1 regulates energy homeostasis and mitochondrial activity. In this issue, Rera et al. (2011) show that dPGC-1 overexpression in Drosophila intestinal stem cells and their immediate progeny extends organismal life span and protects against age-related loss of intestinal homeostasis and integrity, thereby establishing a link between mitochondria, tissue stem cells, and aging.

Original languageEnglish
Pages (from-to)571-572
Number of pages2
JournalCell Metabolism
Volume14
Issue number5
DOIs
Publication statusPublished - 2 Nov 2011
Externally publishedYes

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