A preliminary Raman spectroscopic study of native zinc-insulin crystals

Nai Teng Yu; C. S. Liu; J. Culver; D. C. O'Shea

doi:10.1016/0005-2795(72)90153-5

A preliminary Raman spectroscopic study of native zinc-insulin crystals

Nai Teng Yu^*
, C. S. Liu
, J. Culver
, D. C. O'Shea

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

18 Citations (Scopus)

Abstract

A Raman spectrum of rhombohedral zinc-insulin crystals is reported and partially interpreted. One interesting finding is that the intrachain disulfide bond, A6-11, may have a local geometry different from that of the interchain disulfide bonds, B7-A7 and B19-A20. Another finding is that the amide III region consists of three resolved peaks at 1239, 1270 and 1288 cm^-1, indicating the existence of three distinct structural components in the polypeptide chains of the insulin crystals. These interpretations are compared with the X-ray crystallographic results of Hodgkin and co-workers.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	BBA - Protein Structure
Volume	263
Issue number	1
DOIs	https://doi.org/10.1016/0005-2795(72)90153-5
Publication status	Published - 15 Mar 1972
Externally published	Yes

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10.1016/0005-2795(72)90153-5

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title = "A preliminary Raman spectroscopic study of native zinc-insulin crystals",

abstract = "A Raman spectrum of rhombohedral zinc-insulin crystals is reported and partially interpreted. One interesting finding is that the intrachain disulfide bond, A6-11, may have a local geometry different from that of the interchain disulfide bonds, B7-A7 and B19-A20. Another finding is that the amide III region consists of three resolved peaks at 1239, 1270 and 1288 cm-1, indicating the existence of three distinct structural components in the polypeptide chains of the insulin crystals. These interpretations are compared with the X-ray crystallographic results of Hodgkin and co-workers.",

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year = "1972",

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AU - Yu, Nai Teng

AU - Liu, C. S.

AU - Culver, J.

AU - O'Shea, D. C.

PY - 1972/3/15

Y1 - 1972/3/15

N2 - A Raman spectrum of rhombohedral zinc-insulin crystals is reported and partially interpreted. One interesting finding is that the intrachain disulfide bond, A6-11, may have a local geometry different from that of the interchain disulfide bonds, B7-A7 and B19-A20. Another finding is that the amide III region consists of three resolved peaks at 1239, 1270 and 1288 cm-1, indicating the existence of three distinct structural components in the polypeptide chains of the insulin crystals. These interpretations are compared with the X-ray crystallographic results of Hodgkin and co-workers.

AB - A Raman spectrum of rhombohedral zinc-insulin crystals is reported and partially interpreted. One interesting finding is that the intrachain disulfide bond, A6-11, may have a local geometry different from that of the interchain disulfide bonds, B7-A7 and B19-A20. Another finding is that the amide III region consists of three resolved peaks at 1239, 1270 and 1288 cm-1, indicating the existence of three distinct structural components in the polypeptide chains of the insulin crystals. These interpretations are compared with the X-ray crystallographic results of Hodgkin and co-workers.

UR - https://openalex.org/W2038666400

UR - https://www.scopus.com/pages/publications/0015507925

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DO - 10.1016/0005-2795(72)90153-5

M3 - Journal Article

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JO - BBA - Protein Structure

JF - BBA - Protein Structure

IS - 1

ER -

A preliminary Raman spectroscopic study of native zinc-insulin crystals

Abstract

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