Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model

Yiming FU; Minh PHAM BINH; Sicong He; Zhongya QIN; Ting Xie; Jianan Qu

doi:10.1117/12.2692203

Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model

Yiming FU^*, Minh PHAM BINH, Sicong He, Zhongya QIN, Ting Xie, Jianan Qu

^*Corresponding author for this work

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

Abstract

Glaucoma is characterized by the irreversible retinal ganglion cells (RGCs) loss and has received great research and clinical attention due to its complex mechanism and loss of effective treatment. Longitudinal in vivo study on glaucoma in mouse model can be a promising approach to unveil the mechanism of glaucoma. In this paper, we use a silicon oil (SO) induced glaucoma model on mouse and the adaptive optics two photon microscope system to evaluate whether the aberration from both mouse eye and SO can be corrected and then longitudinal imaging with subcellular resolution on the mouse retina can be achieved.

Original language	English
Title of host publication	Ophthalmic Technologies XXXIV
Editors	Daniel X. Hammer, Kostadinka Bizheva, Georg Schuele
Publisher	SPIE
ISBN (Electronic)	9781510669079
DOIs	https://doi.org/10.1117/12.2692203
Publication status	Published - 2024
Event	Ophthalmic Technologies XXXIV 2024 - San Francisco, United States Duration: 27 Jan 2024 → 1 Feb 2024

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12824
ISSN (Print)	1605-7422

Conference

Conference	Ophthalmic Technologies XXXIV 2024
Country/Territory	United States
City	San Francisco
Period	27/01/24 → 1/02/24

Bibliographical note

Publisher Copyright:
© 2024 SPIE.

Keywords

Adaptive optics two photon microscopes
RGCs degeneration
glaucoma
retina imaging

Access to Document

10.1117/12.2692203

Cite this

FU, Y., PHAM BINH, M., He, S., QIN, Z., Xie, T., & Qu, J. (2024). Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model. In D. X. Hammer, K. Bizheva, & G. Schuele (Eds.), Ophthalmic Technologies XXXIV Article 128240H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12824). SPIE. https://doi.org/10.1117/12.2692203

FU, Yiming ; PHAM BINH, Minh ; He, Sicong et al. / Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model. Ophthalmic Technologies XXXIV. editor / Daniel X. Hammer ; Kostadinka Bizheva ; Georg Schuele. SPIE, 2024. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model",

abstract = "Glaucoma is characterized by the irreversible retinal ganglion cells (RGCs) loss and has received great research and clinical attention due to its complex mechanism and loss of effective treatment. Longitudinal in vivo study on glaucoma in mouse model can be a promising approach to unveil the mechanism of glaucoma. In this paper, we use a silicon oil (SO) induced glaucoma model on mouse and the adaptive optics two photon microscope system to evaluate whether the aberration from both mouse eye and SO can be corrected and then longitudinal imaging with subcellular resolution on the mouse retina can be achieved.",

keywords = "Adaptive optics two photon microscopes, RGCs degeneration, glaucoma, retina imaging",

author = "Yiming FU and \{PHAM BINH\}, Minh and Sicong He and Zhongya QIN and Ting Xie and Jianan Qu",

note = "Publisher Copyright: {\textcopyright} 2024 SPIE.; Ophthalmic Technologies XXXIV 2024 ; Conference date: 27-01-2024 Through 01-02-2024",

year = "2024",

doi = "10.1117/12.2692203",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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editor = "Hammer, \{Daniel X.\} and Kostadinka Bizheva and Georg Schuele",

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FU, Y, PHAM BINH, M, He, S, QIN, Z, Xie, T & Qu, J 2024, Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model. in DX Hammer, K Bizheva & G Schuele (eds), Ophthalmic Technologies XXXIV., 128240H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12824, SPIE, Ophthalmic Technologies XXXIV 2024, San Francisco, United States, 27/01/24. https://doi.org/10.1117/12.2692203

Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model. / FU, Yiming; PHAM BINH, Minh; He, Sicong et al.
Ophthalmic Technologies XXXIV. ed. / Daniel X. Hammer; Kostadinka Bizheva; Georg Schuele. SPIE, 2024. 128240H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12824).

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

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T1 - Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model

AU - FU, Yiming

AU - PHAM BINH, Minh

AU - He, Sicong

AU - QIN, Zhongya

AU - Xie, Ting

AU - Qu, Jianan

PY - 2024

Y1 - 2024

N2 - Glaucoma is characterized by the irreversible retinal ganglion cells (RGCs) loss and has received great research and clinical attention due to its complex mechanism and loss of effective treatment. Longitudinal in vivo study on glaucoma in mouse model can be a promising approach to unveil the mechanism of glaucoma. In this paper, we use a silicon oil (SO) induced glaucoma model on mouse and the adaptive optics two photon microscope system to evaluate whether the aberration from both mouse eye and SO can be corrected and then longitudinal imaging with subcellular resolution on the mouse retina can be achieved.

AB - Glaucoma is characterized by the irreversible retinal ganglion cells (RGCs) loss and has received great research and clinical attention due to its complex mechanism and loss of effective treatment. Longitudinal in vivo study on glaucoma in mouse model can be a promising approach to unveil the mechanism of glaucoma. In this paper, we use a silicon oil (SO) induced glaucoma model on mouse and the adaptive optics two photon microscope system to evaluate whether the aberration from both mouse eye and SO can be corrected and then longitudinal imaging with subcellular resolution on the mouse retina can be achieved.

KW - Adaptive optics two photon microscopes

KW - RGCs degeneration

KW - glaucoma

KW - retina imaging

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DO - 10.1117/12.2692203

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Ophthalmic Technologies XXXIV

A2 - Hammer, Daniel X.

A2 - Bizheva, Kostadinka

A2 - Schuele, Georg

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ER -

FU Y, PHAM BINH M, He S, QIN Z, Xie T , Qu J. Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model. In Hammer DX, Bizheva K, Schuele G, editors, Ophthalmic Technologies XXXIV. SPIE. 2024. 128240H. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2692203

Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model

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