TY - JOUR
T1 - Aggregation-induced emission
T2 - An emerging concept in brain science
AU - Wu, Qian
AU - Li, Youmei
AU - Wang, Lei
AU - Wang, Dong
AU - Tang, Ben Zhong
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/7
Y1 - 2022/7
N2 - As an emerging concept in brain science, aggregation-induced emission (AIE) has captivated much interest by virtue of the unique superiority of AIE fluorophores in terms of emission intensity, imaging resolution, biocompatibility and photosensitivity. This review mainly overviews the current state-of-art advances of AIE fluorophores achieving the superb performance in brain imaging and therapy, which facilitate deep tissue penetration, high contrast to autofluorescence and efficient blood-brain barrier (BBB) crossing by rational molecular design and functionalized strategies. We expect this review serve as a modest spur to push forward the blooming growth of research in this fertile field.
AB - As an emerging concept in brain science, aggregation-induced emission (AIE) has captivated much interest by virtue of the unique superiority of AIE fluorophores in terms of emission intensity, imaging resolution, biocompatibility and photosensitivity. This review mainly overviews the current state-of-art advances of AIE fluorophores achieving the superb performance in brain imaging and therapy, which facilitate deep tissue penetration, high contrast to autofluorescence and efficient blood-brain barrier (BBB) crossing by rational molecular design and functionalized strategies. We expect this review serve as a modest spur to push forward the blooming growth of research in this fertile field.
KW - Aggregation-induced emission
KW - Blood-brain barrier penetration
KW - Brain science
KW - Cerebrovascular imaging
KW - Molecular design
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000832951300001
UR - https://openalex.org/W4281263346
UR - https://www.scopus.com/pages/publications/85130880763
U2 - 10.1016/j.biomaterials.2022.121581
DO - 10.1016/j.biomaterials.2022.121581
M3 - Journal Article
C2 - 35633591
SN - 0142-9612
VL - 286
JO - Biomaterials
JF - Biomaterials
M1 - 121581
ER -