An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2

Anakin C.S. Leung; Engui Zhao; Ryan T.K. Kwok; Jacky W.Y. Lam; Chris W.T. Leung; Haiqin Deng; Ben Zhong Tang

doi:10.1039/c6tb01734g

An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H₂O₂

Anakin C.S. Leung, Engui Zhao, Ryan T.K. Kwok, Jacky W.Y. Lam, Chris W.T. Leung, Haiqin Deng, Ben Zhong Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

23 Citations (Scopus)

Abstract

A bioprobe, TPE-Zn₂BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H₂O₂. TPE-Zn₂BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

Original language	English
Pages (from-to)	5510-5514
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	33
DOIs	https://doi.org/10.1039/c6tb01734g
Publication status	Published - 2016

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© The Royal Society of Chemistry 2016.

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title = "An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2",

abstract = "A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.",

author = "Leung, \{Anakin C.S.\} and Engui Zhao and Kwok, \{Ryan T.K.\} and Lam, \{Jacky W.Y.\} and Leung, \{Chris W.T.\} and Haiqin Deng and Tang, \{Ben Zhong\}",

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language = "English",

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T1 - An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2

AU - Leung, Anakin C.S.

AU - Zhao, Engui

AU - Kwok, Ryan T.K.

AU - Lam, Jacky W.Y.

AU - Leung, Chris W.T.

AU - Deng, Haiqin

AU - Tang, Ben Zhong

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

AB - A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000382016600002

UR - https://openalex.org/W2478523294

UR - https://www.scopus.com/pages/publications/85023158401

U2 - 10.1039/c6tb01734g

DO - 10.1039/c6tb01734g

M3 - Journal Article

SN - 2050-7518

VL - 4

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EP - 5514

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 33

ER -

An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H₂O₂

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