An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy

Hailing Zhao; Nan Li; Caixia Ma; Zhengwei Wei; Qiya Zeng; Keyi Zhang; Na Zhao; Ben Zhong Tang

doi:10.1016/j.cclet.2022.07.042

An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy

Hailing Zhao, Nan Li, Caixia Ma, Zhengwei Wei, Qiya Zeng, Keyi Zhang, Na Zhao^*, Ben Zhong Tang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

39 Citations (Scopus)

Abstract

Two red-emissive luminogens (TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy.

Original language	English
Article number	107699
Journal	Chinese Chemical Letters
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.cclet.2022.07.042
Publication status	Published - Apr 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aggregation-induced emission
Fluorescent probe
Long-term imaging
Photodynamic therapy
Plasma membrane

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10.1016/j.cclet.2022.07.042

Cite this

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title = "An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy",

abstract = "Two red-emissive luminogens (TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy.",

keywords = "Aggregation-induced emission, Fluorescent probe, Long-term imaging, Photodynamic therapy, Plasma membrane",

author = "Hailing Zhao and Nan Li and Caixia Ma and Zhengwei Wei and Qiya Zeng and Keyi Zhang and Na Zhao and Tang, \{Ben Zhong\}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

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doi = "10.1016/j.cclet.2022.07.042",

language = "English",

volume = "34",

journal = "Chinese Chemical Letters",

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TY - JOUR

T1 - An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy

AU - Zhao, Hailing

AU - Li, Nan

AU - Ma, Caixia

AU - Wei, Zhengwei

AU - Zeng, Qiya

AU - Zhang, Keyi

AU - Zhao, Na

AU - Tang, Ben Zhong

PY - 2023/4

Y1 - 2023/4

N2 - Two red-emissive luminogens (TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy.

AB - Two red-emissive luminogens (TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy.

KW - Aggregation-induced emission

KW - Fluorescent probe

KW - Long-term imaging

KW - Photodynamic therapy

KW - Plasma membrane

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000926741300001

UR - https://openalex.org/W4286751380

UR - https://www.scopus.com/pages/publications/85147823486

U2 - 10.1016/j.cclet.2022.07.042

DO - 10.1016/j.cclet.2022.07.042

M3 - Journal Article

SN - 1001-8417

VL - 34

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 4

M1 - 107699

ER -

An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy

Abstract

Bibliographical note

UN SDGs

Keywords

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