Andrographolactone, a unique diterpene from Andrographis paniculata

Guo Cai Wang; Ying Wang; Ian D. Williams; Herman Ho Yung Sung; Xiao Qi Zhang; Dong Mei Zhang; Ren Wang Jiang; Xin Sheng Yao; Wen Cai Ye

doi:10.1016/j.tetlet.2009.05.097

Andrographolactone, a unique diterpene from Andrographis paniculata

Guo Cai Wang, Ying Wang, Ian D. Williams, Herman Ho Yung Sung, Xiao Qi Zhang, Dong Mei Zhang, Ren Wang Jiang, Xin Sheng Yao, Wen Cai Ye^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal Article › peer-review

27 Citations (Scopus)

Abstract

Andrographolactone (1), possessing an unprecedented diterpene skeleton, was isolated from the EtOAc extract of the aerial parts of Andrographis paniculata. Its structure was established by NMR, IR, UV, and HRESIMS data and subsequently confirmed by X-ray diffraction analysis. A possible biogenetic pathway of 1 was also proposed. Bioassay showed that 1 exhibited cytotoxic activity.

Original language	English
Pages (from-to)	4824-4826
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2009.05.097
Publication status	Published - 26 Aug 2009

Keywords

Acanthaceae
Andrographis paniculata
Andrographolactone
Diterpene

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10.1016/j.tetlet.2009.05.097

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@article{5d66033159c744bf8e99ca44e067b5f1,

title = "Andrographolactone, a unique diterpene from Andrographis paniculata",

abstract = "Andrographolactone (1), possessing an unprecedented diterpene skeleton, was isolated from the EtOAc extract of the aerial parts of Andrographis paniculata. Its structure was established by NMR, IR, UV, and HRESIMS data and subsequently confirmed by X-ray diffraction analysis. A possible biogenetic pathway of 1 was also proposed. Bioassay showed that 1 exhibited cytotoxic activity.",

keywords = "Acanthaceae, Andrographis paniculata, Andrographolactone, Diterpene",

author = "Wang, \{Guo Cai\} and Ying Wang and Williams, \{Ian D.\} and Sung, \{Herman Ho Yung\} and Zhang, \{Xiao Qi\} and Zhang, \{Dong Mei\} and Jiang, \{Ren Wang\} and Yao, \{Xin Sheng\} and Ye, \{Wen Cai\}",

year = "2009",

month = aug,

day = "26",

doi = "10.1016/j.tetlet.2009.05.097",

language = "English",

volume = "50",

pages = "4824--4826",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "34",

}

TY - JOUR

T1 - Andrographolactone, a unique diterpene from Andrographis paniculata

AU - Wang, Guo Cai

AU - Wang, Ying

AU - Williams, Ian D.

AU - Sung, Herman Ho Yung

AU - Zhang, Xiao Qi

AU - Zhang, Dong Mei

AU - Jiang, Ren Wang

AU - Yao, Xin Sheng

AU - Ye, Wen Cai

PY - 2009/8/26

Y1 - 2009/8/26

N2 - Andrographolactone (1), possessing an unprecedented diterpene skeleton, was isolated from the EtOAc extract of the aerial parts of Andrographis paniculata. Its structure was established by NMR, IR, UV, and HRESIMS data and subsequently confirmed by X-ray diffraction analysis. A possible biogenetic pathway of 1 was also proposed. Bioassay showed that 1 exhibited cytotoxic activity.

AB - Andrographolactone (1), possessing an unprecedented diterpene skeleton, was isolated from the EtOAc extract of the aerial parts of Andrographis paniculata. Its structure was established by NMR, IR, UV, and HRESIMS data and subsequently confirmed by X-ray diffraction analysis. A possible biogenetic pathway of 1 was also proposed. Bioassay showed that 1 exhibited cytotoxic activity.

KW - Acanthaceae

KW - Andrographis paniculata

KW - Andrographolactone

KW - Diterpene

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000268508900006

UR - https://openalex.org/W2063865885

UR - https://www.scopus.com/pages/publications/67649856628

U2 - 10.1016/j.tetlet.2009.05.097

DO - 10.1016/j.tetlet.2009.05.097

M3 - Journal Article

SN - 0040-4039

VL - 50

SP - 4824

EP - 4826

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

Andrographolactone, a unique diterpene from Andrographis paniculata

Abstract

Keywords

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