TY - JOUR
T1 - Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus
AU - Li, Ning
AU - Zhang, Jia Yu
AU - Zeng, Ke Wu
AU - Zhang, Liang
AU - Che, Yan Yun
AU - Tu, Peng Fei
PY - 2012/9
Y1 - 2012/9
N2 - Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC50 values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 μM respectively.
AB - Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC50 values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 μM respectively.
KW - Anti-inflammatory
KW - Homoisoflavonoids
KW - Inhibitory effects of nitric oxide production
KW - Ophiopogon japonicus
KW - Ophiopogonanone H
KW - Ophiopogonone E
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000308116600010
UR - https://www.scopus.com/pages/publications/84863987076
U2 - 10.1016/j.fitote.2012.05.011
DO - 10.1016/j.fitote.2012.05.011
M3 - Journal Article
C2 - 22626747
SN - 0367-326X
VL - 83
SP - 1042
EP - 1045
JO - Fitoterapia
JF - Fitoterapia
IS - 6
ER -