Atomically precise photothermal nanomachines

Jing Chen; Peilin Gu; Guangliu Ran; Yu Zhang; Mingqiang Li; Bin Chen; Hui Lu; Ying Zi Han; Wenkai Zhang; Zichao Tang; Qinglong Yan; Rui Sun; Xiaobin Fu; Guorui Chen; Zhiwen Shi; Shiyong Wang; Xiaoguo Liu; Jiang Li; Lihua Wang; Ying Zhu; Jianlei Shen; Ben Zhong Tang; Chunhai Fan

doi:10.1038/s41563-023-01721-y

Atomically precise photothermal nanomachines

Jing Chen, Peilin Gu, Guangliu Ran, Yu Zhang, Mingqiang Li, Bin Chen, Hui Lu, Ying Zi Han, Wenkai Zhang, Zichao Tang, Qinglong Yan, Rui Sun, Xiaobin Fu, Guorui Chen, Zhiwen Shi, Shiyong Wang, Xiaoguo Liu, Jiang Li, Lihua Wang, Ying Zhu^*Jianlei Shen^*, Ben Zhong Tang^*, Chunhai Fan^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

74 Citations (Scopus)

Abstract

Interfacing molecular machines to inorganic nanoparticles can, in principle, lead to hybrid nanomachines with extended functions. Here we demonstrate a ligand engineering approach to develop atomically precise hybrid nanomachines by interfacing gold nanoclusters with tetraphenylethylene molecular rotors. When gold nanoclusters are irradiated with near-infrared light, the rotation of surface-decorated tetraphenylethylene moieties actively dissipates the absorbed energy to sustain the photothermal nanomachine with an intact structure and steady efficiency. Solid-state nuclear magnetic resonance and femtosecond transient absorption spectroscopy reveal that the photogenerated hot electrons are rapidly cooled down within picoseconds via electron–phonon coupling in the nanomachine. We find that the nanomachine remains structurally and functionally intact in mammalian cells and in vivo. A single dose of near-infrared irradiation can effectively ablate tumours without recurrence in tumour-bearing mice, which shows promise in the development of nanomachine-based theranostics.

Original language	English
Pages (from-to)	271-280
Number of pages	10
Journal	Nature Materials
Volume	23
Issue number	2
DOIs	https://doi.org/10.1038/s41563-023-01721-y
Publication status	Published - Feb 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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abstract = "Interfacing molecular machines to inorganic nanoparticles can, in principle, lead to hybrid nanomachines with extended functions. Here we demonstrate a ligand engineering approach to develop atomically precise hybrid nanomachines by interfacing gold nanoclusters with tetraphenylethylene molecular rotors. When gold nanoclusters are irradiated with near-infrared light, the rotation of surface-decorated tetraphenylethylene moieties actively dissipates the absorbed energy to sustain the photothermal nanomachine with an intact structure and steady efficiency. Solid-state nuclear magnetic resonance and femtosecond transient absorption spectroscopy reveal that the photogenerated hot electrons are rapidly cooled down within picoseconds via electron–phonon coupling in the nanomachine. We find that the nanomachine remains structurally and functionally intact in mammalian cells and in vivo. A single dose of near-infrared irradiation can effectively ablate tumours without recurrence in tumour-bearing mice, which shows promise in the development of nanomachine-based theranostics.",

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AU - Ran, Guangliu

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AU - Chen, Bin

AU - Lu, Hui

AU - Han, Ying Zi

AU - Zhang, Wenkai

AU - Tang, Zichao

AU - Yan, Qinglong

AU - Sun, Rui

AU - Fu, Xiaobin

AU - Chen, Guorui

AU - Shi, Zhiwen

AU - Wang, Shiyong

AU - Liu, Xiaoguo

AU - Li, Jiang

AU - Wang, Lihua

AU - Zhu, Ying

AU - Shen, Jianlei

AU - Tang, Ben Zhong

AU - Fan, Chunhai

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N2 - Interfacing molecular machines to inorganic nanoparticles can, in principle, lead to hybrid nanomachines with extended functions. Here we demonstrate a ligand engineering approach to develop atomically precise hybrid nanomachines by interfacing gold nanoclusters with tetraphenylethylene molecular rotors. When gold nanoclusters are irradiated with near-infrared light, the rotation of surface-decorated tetraphenylethylene moieties actively dissipates the absorbed energy to sustain the photothermal nanomachine with an intact structure and steady efficiency. Solid-state nuclear magnetic resonance and femtosecond transient absorption spectroscopy reveal that the photogenerated hot electrons are rapidly cooled down within picoseconds via electron–phonon coupling in the nanomachine. We find that the nanomachine remains structurally and functionally intact in mammalian cells and in vivo. A single dose of near-infrared irradiation can effectively ablate tumours without recurrence in tumour-bearing mice, which shows promise in the development of nanomachine-based theranostics.

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Atomically precise photothermal nanomachines

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