TY - JOUR
T1 - Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles
AU - Li, Youmei
AU - Wu, Qian
AU - Kang, Miaomiao
AU - Song, Nan
AU - Wang, Dong
AU - Tang, Ben Zhong
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/2
Y1 - 2020/2
N2 - Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficiency of AIE photosensitizers is highly desirable but still remain a challenging task. Herein, a novel strategy is designed and performed for boosting PDT effect based on stimuli-responsive nano-micelles as extraordinary carriers for an AIE photosensitizer, namely MeTTMN. Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly superior to commercially available nano-micelles carried MeTTMN. This study thus offers an ideal template for fluorescence imaging-guided PDT, as well as a promising candidate for clinical trials.
AB - Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficiency of AIE photosensitizers is highly desirable but still remain a challenging task. Herein, a novel strategy is designed and performed for boosting PDT effect based on stimuli-responsive nano-micelles as extraordinary carriers for an AIE photosensitizer, namely MeTTMN. Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly superior to commercially available nano-micelles carried MeTTMN. This study thus offers an ideal template for fluorescence imaging-guided PDT, as well as a promising candidate for clinical trials.
KW - Aggregation-induced emission
KW - High ROS generation efficiency
KW - High loading capacity
KW - Photodynamic therapy
KW - Stimuli-responsive nanoparticles
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000514748200028
UR - https://openalex.org/W2997651623
UR - https://www.scopus.com/pages/publications/85077327174
U2 - 10.1016/j.biomaterials.2019.119749
DO - 10.1016/j.biomaterials.2019.119749
M3 - Journal Article
C2 - 31918230
SN - 0142-9612
VL - 232
JO - Biomaterials
JF - Biomaterials
M1 - 119749
ER -
