Calcium Signaling in Extraembryonic Domains During Early Teleost Development

It is becoming recognized that the extraembryonic domains of developing vertebrates, that is, those that make no cellular contribution to the embryo proper, act as important signaling centers that induce and pattern the germ layers and help establish the key embryonic axes. In the embryos of teleost fish, in particular, significant progress has been made in understanding how signaling activity in extraembryonic domains, such as the enveloping layer, the yolk syncytial layer, and the yolk cell, might help regulate development via a combination of inductive interactions, cellular dynamics, and localized gene expression. Ca²⁺ signaling in a variety of forms that include propagating waves and standing gradients is a feature found in all three teleostean extraembryonic domains. This leads us to propose that in addition to their other well-characterized signaling activities, extraembryonic domains are well suited (due to their relative stability and continuity) to act as Ca²⁺ signaling centers and conduits.