TY - JOUR
T1 - Catalytic Enantioselective Synthesis of 2,3-Dihydrobenzo[b]oxepines via Asymmetric Oxetane Opening by Internal Carbon Nucleophiles
AU - Zhang, Tianyu
AU - Zhuang, Han
AU - Tang, Luning
AU - Han, Zhengyu
AU - Guo, Wengang
AU - Huang, Hai
AU - Sun, Jianwei
N1 - Publisher Copyright:
© 2021 American Chemical Society
PY - 2022/1/14
Y1 - 2022/1/14
N2 - An intramolecular C–C formation process based on catalytic asymmetric oxetane opening by carbon nucleophiles has been developed, which provides rapid access to a range of valuable enantioenriched 2,3-dihydrobenzo[b]oxepines. With the combination of Sc(OTf)3 and a Box ligand, good chemical efficiency and enantioselectivity were achieved under mild conditions. The products are also useful precursors to other valuable structures, such as the bicyclo[3.2.2]nonane derivatives.
AB - An intramolecular C–C formation process based on catalytic asymmetric oxetane opening by carbon nucleophiles has been developed, which provides rapid access to a range of valuable enantioenriched 2,3-dihydrobenzo[b]oxepines. With the combination of Sc(OTf)3 and a Box ligand, good chemical efficiency and enantioselectivity were achieved under mild conditions. The products are also useful precursors to other valuable structures, such as the bicyclo[3.2.2]nonane derivatives.
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000733803500001
UR - https://openalex.org/W4200589816
UR - https://www.scopus.com/pages/publications/85122035268
U2 - 10.1021/acs.orglett.1c03852
DO - 10.1021/acs.orglett.1c03852
M3 - Journal Article
C2 - 34914391
SN - 1523-7060
VL - 24
SP - 207
EP - 212
JO - Organic Letters
JF - Organic Letters
IS - 1
ER -