Chemical biology tools take the strain: Bioorthogonal chemistry

Kenward Vong; Katsunori Tanaka

doi:10.1038/s41589-024-01780-5

Chemical biology tools take the strain: Bioorthogonal chemistry

Kenward Vong
, Katsunori Tanaka^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Comment/debate

5 Citations (Scopus)

Abstract

Bioorthogonal chemistry has become a mainstay technique used by chemists and biologists alike. Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC). Owing to its robustness, simplicity and applicability to living systems, SPAAC continues to have a pivotal role in shaping developments in the field.

Original language	English
Pages (from-to)	24-26
Number of pages	3
Journal	Nature Chemical Biology
Volume	21
Issue number	1
Early online date	24 Dec 2024
DOIs	https://doi.org/10.1038/s41589-024-01780-5
Publication status	Published - Jan 2025

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Publisher Copyright:
© Springer Nature America, Inc. 2024.

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abstract = "Bioorthogonal chemistry has become a mainstay technique used by chemists and biologists alike. Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC). Owing to its robustness, simplicity and applicability to living systems, SPAAC continues to have a pivotal role in shaping developments in the field.",

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Chemical biology tools take the strain: Bioorthogonal chemistry

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