TY - JOUR
T1 - Chemical biology tools take the strain
T2 - Bioorthogonal chemistry
AU - Vong, Kenward
AU - Tanaka, Katsunori
N1 - Publisher Copyright:
© Springer Nature America, Inc. 2024.
PY - 2025/1
Y1 - 2025/1
N2 - Bioorthogonal chemistry has become a mainstay technique used by chemists and biologists alike. Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC). Owing to its robustness, simplicity and applicability to living systems, SPAAC continues to have a pivotal role in shaping developments in the field.
AB - Bioorthogonal chemistry has become a mainstay technique used by chemists and biologists alike. Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC). Owing to its robustness, simplicity and applicability to living systems, SPAAC continues to have a pivotal role in shaping developments in the field.
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001382995900005
UR - https://openalex.org/W4405738026
UR - https://www.scopus.com/pages/publications/85212818950
U2 - 10.1038/s41589-024-01780-5
DO - 10.1038/s41589-024-01780-5
M3 - Comment/debate
C2 - 39719490
SN - 1552-4450
VL - 21
SP - 24
EP - 26
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 1
ER -