Ciliary neurotrophic factor and its receptor complex

Nancy Y. Ip; George D. Yancopoulos

doi:10.1016/0955-2235(92)90028-G

Ciliary neurotrophic factor and its receptor complex

Nancy Y. Ip^*, George D. Yancopoulos

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

128 Citations (Scopus)

Abstract

Ciliary neurotrophic factor (CNTF), originally identified for its ability to promote survival of neurons of the ciliary ganglion, is now known to have additional survival and differentiative actions on cells of the nervous system. CNTF is, however, unrelated in structure to the nerve growth factor family of neurotrophic factors. Instead, CNTF is distantly related to, and in fact shares receptor components with, a number of hemopoietic cytokines. This review focuses on the biological actions of CNTF, the shared and unique features of the CNTF receptor complex and signaling pathways, and the distribution of CNTF and its receptor during development, in the adult and in response to injury.

Original language	English
Pages (from-to)	139-155
Number of pages	17
Journal	Progress in Growth Factor Research
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0955-2235(92)90028-G
Publication status	Published - 1992
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Ciliary neurotrophic factor (CNTF)
cytokine receptors
cytokines
gp130
interleukin-6 (IL-6)
leukemia inhibitory factor (LIF)
nerve growth factor (NGF)
neurotrophic factor

Access to Document

10.1016/0955-2235(92)90028-G

Cite this

@article{0570cfbb138d402397b1ea23ff4a3bb2,

title = "Ciliary neurotrophic factor and its receptor complex",

abstract = "Ciliary neurotrophic factor (CNTF), originally identified for its ability to promote survival of neurons of the ciliary ganglion, is now known to have additional survival and differentiative actions on cells of the nervous system. CNTF is, however, unrelated in structure to the nerve growth factor family of neurotrophic factors. Instead, CNTF is distantly related to, and in fact shares receptor components with, a number of hemopoietic cytokines. This review focuses on the biological actions of CNTF, the shared and unique features of the CNTF receptor complex and signaling pathways, and the distribution of CNTF and its receptor during development, in the adult and in response to injury.",

keywords = "Ciliary neurotrophic factor (CNTF), cytokine receptors, cytokines, gp130, interleukin-6 (IL-6), leukemia inhibitory factor (LIF), nerve growth factor (NGF), neurotrophic factor",

author = "Ip, \{Nancy Y.\} and Yancopoulos, \{George D.\}",

year = "1992",

doi = "10.1016/0955-2235(92)90028-G",

language = "English",

volume = "4",

pages = "139--155",

journal = "Progress in Growth Factor Research",

issn = "0955-2235",

publisher = "Pergamon Press Ltd.",

number = "2",

}

TY - JOUR

T1 - Ciliary neurotrophic factor and its receptor complex

AU - Ip, Nancy Y.

AU - Yancopoulos, George D.

PY - 1992

Y1 - 1992

N2 - Ciliary neurotrophic factor (CNTF), originally identified for its ability to promote survival of neurons of the ciliary ganglion, is now known to have additional survival and differentiative actions on cells of the nervous system. CNTF is, however, unrelated in structure to the nerve growth factor family of neurotrophic factors. Instead, CNTF is distantly related to, and in fact shares receptor components with, a number of hemopoietic cytokines. This review focuses on the biological actions of CNTF, the shared and unique features of the CNTF receptor complex and signaling pathways, and the distribution of CNTF and its receptor during development, in the adult and in response to injury.

AB - Ciliary neurotrophic factor (CNTF), originally identified for its ability to promote survival of neurons of the ciliary ganglion, is now known to have additional survival and differentiative actions on cells of the nervous system. CNTF is, however, unrelated in structure to the nerve growth factor family of neurotrophic factors. Instead, CNTF is distantly related to, and in fact shares receptor components with, a number of hemopoietic cytokines. This review focuses on the biological actions of CNTF, the shared and unique features of the CNTF receptor complex and signaling pathways, and the distribution of CNTF and its receptor during development, in the adult and in response to injury.

KW - Ciliary neurotrophic factor (CNTF)

KW - cytokine receptors

KW - cytokines

KW - gp130

KW - interleukin-6 (IL-6)

KW - leukemia inhibitory factor (LIF)

KW - nerve growth factor (NGF)

KW - neurotrophic factor

UR - https://openalex.org/W2025199687

UR - https://www.scopus.com/pages/publications/0027025606

U2 - 10.1016/0955-2235(92)90028-G

DO - 10.1016/0955-2235(92)90028-G

M3 - Journal Article

C2 - 1338574

SN - 0955-2235

VL - 4

SP - 139

EP - 155

JO - Progress in Growth Factor Research

JF - Progress in Growth Factor Research

IS - 2

ER -

Ciliary neurotrophic factor and its receptor complex

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this