TY - JOUR
T1 - Colon cancer associated transcripts in human cancers
AU - Chen, Yincong
AU - Xie, Haibiao
AU - Gao, Qunjun
AU - Zhan, Hengji
AU - Xiao, Huizhong
AU - Zou, Yifan
AU - Zhang, Fuyou
AU - Liu, Yuchen
AU - Li, Jianfa
N1 - Publisher Copyright:
© 2017 Elsevier Masson SAS
PY - 2017/10
Y1 - 2017/10
N2 - Long non-coding RNAs serve as important regulators in complicated cellular activities, including cell differentiation, proliferation and death. Dysregulation of long non-coding RNAs occurs in the formation and progression of cancers. The family of colon cancer associated transcripts, long non-coding RNAs colon cancer associated transcript-1 and colon cancer associated transcript-2 are known as oncogenes involved in various cancers. Colon cancer associated transcript-1 is a novel lncRNA located in 8q24.2, and colon cancer associated transcript-2 maps to the 8q24.21 region encompassing rs6983267. Colon cancer associated transcripts have close associations with clinical characteristics, such as lymph node metastasis, high TNM stage and short overall survival. Knockdown of them can reverse the malignant phenotypes of cancer cells, including proliferation, migration, invasion and apoptosis. Moreover, they can increase the expression level of c-MYC and oncogenic microRNAs via activating a series of complex mechanisms. In brief, the family of colon cancer associated transcripts may serve as potential biomarkers or therapeutic targets for human cancers.
AB - Long non-coding RNAs serve as important regulators in complicated cellular activities, including cell differentiation, proliferation and death. Dysregulation of long non-coding RNAs occurs in the formation and progression of cancers. The family of colon cancer associated transcripts, long non-coding RNAs colon cancer associated transcript-1 and colon cancer associated transcript-2 are known as oncogenes involved in various cancers. Colon cancer associated transcript-1 is a novel lncRNA located in 8q24.2, and colon cancer associated transcript-2 maps to the 8q24.21 region encompassing rs6983267. Colon cancer associated transcripts have close associations with clinical characteristics, such as lymph node metastasis, high TNM stage and short overall survival. Knockdown of them can reverse the malignant phenotypes of cancer cells, including proliferation, migration, invasion and apoptosis. Moreover, they can increase the expression level of c-MYC and oncogenic microRNAs via activating a series of complex mechanisms. In brief, the family of colon cancer associated transcripts may serve as potential biomarkers or therapeutic targets for human cancers.
KW - CCAT1
KW - CCAT2
KW - Therapeutic target
KW - c-MYC
KW - lncRNAs
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000417741000058
UR - https://openalex.org/W2744343309
U2 - 10.1016/j.biopha.2017.07.073
DO - 10.1016/j.biopha.2017.07.073
M3 - Review article
SN - 0753-3322
VL - 94
SP - 531
EP - 540
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -
