Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

David A. Price; Heather Eng; Kathleen A. Farley; Gilles H. Goetz; Yong Huang; Zhaodong Jiao; Amit S. Kalgutkar; Natasha M. Kablaoui; Bhagyashree Khunte; Spiros Liras; Chris Limberakis; Alan M. Mathiowetz; Roger B. Ruggeri; Jun Min Quan; Zhen Yang

doi:10.1039/c7ob00096k

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

David A. Price^*, Heather Eng, Kathleen A. Farley, Gilles H. Goetz, Yong Huang, Zhaodong Jiao, Amit S. Kalgutkar, Natasha M. Kablaoui, Bhagyashree Khunte, Spiros Liras, Chris Limberakis, Alan M. Mathiowetz, Roger B. Ruggeri, Jun Min Quan, Zhen Yang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

28 Citations (Scopus)

Abstract

The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.

Original language	English
Pages (from-to)	2501-2506
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	12
DOIs	https://doi.org/10.1039/c7ob00096k
Publication status	Published - 2017
Externally published	Yes

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© The Royal Society of Chemistry.

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Price, D. A., Eng, H., Farley, K. A., Goetz, G. H., Huang, Y., Jiao, Z., Kalgutkar, A. S., Kablaoui, N. M., Khunte, B., Liras, S., Limberakis, C., Mathiowetz, A. M., Ruggeri, R. B., Quan, J. M., & Yang, Z. (2017). Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue. Organic and Biomolecular Chemistry, 15(12), 2501-2506. https://doi.org/10.1039/c7ob00096k

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title = "Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue",

abstract = "The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.",

author = "Price, \{David A.\} and Heather Eng and Farley, \{Kathleen A.\} and Goetz, \{Gilles H.\} and Yong Huang and Zhaodong Jiao and Kalgutkar, \{Amit S.\} and Kablaoui, \{Natasha M.\} and Bhagyashree Khunte and Spiros Liras and Chris Limberakis and Mathiowetz, \{Alan M.\} and Ruggeri, \{Roger B.\} and Quan, \{Jun Min\} and Zhen Yang",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7ob00096k",

language = "English",

volume = "15",

pages = "2501--2506",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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}

Price, DA, Eng, H, Farley, KA, Goetz, GH, Huang, Y, Jiao, Z, Kalgutkar, AS, Kablaoui, NM, Khunte, B, Liras, S, Limberakis, C, Mathiowetz, AM, Ruggeri, RB, Quan, JM & Yang, Z 2017, 'Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue', Organic and Biomolecular Chemistry, vol. 15, no. 12, pp. 2501-2506. https://doi.org/10.1039/c7ob00096k

TY - JOUR

T1 - Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

AU - Price, David A.

AU - Eng, Heather

AU - Farley, Kathleen A.

AU - Goetz, Gilles H.

AU - Huang, Yong

AU - Jiao, Zhaodong

AU - Kalgutkar, Amit S.

AU - Kablaoui, Natasha M.

AU - Khunte, Bhagyashree

AU - Liras, Spiros

AU - Limberakis, Chris

AU - Mathiowetz, Alan M.

AU - Ruggeri, Roger B.

AU - Quan, Jun Min

AU - Yang, Zhen

PY - 2017

Y1 - 2017

N2 - The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.

AB - The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000397948000005

UR - https://openalex.org/W2591971261

UR - https://www.scopus.com/pages/publications/85016242366

U2 - 10.1039/c7ob00096k

DO - 10.1039/c7ob00096k

M3 - Journal Article

C2 - 28266673

SN - 1477-0520

VL - 15

SP - 2501

EP - 2506

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 12

ER -

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

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