Comparative study of PID control and model predictive control for a microfluidic electroporation system

M. Ghadami; H. Shagoshtasbi; M. J. Mahjoob; Y. K. Lee

doi:10.1109/NEMS.2013.6559867

Comparative study of PID control and model predictive control for a microfluidic electroporation system

M. Ghadami, H. Shagoshtasbi, M. J. Mahjoob, Y. K. Lee^*

^*Corresponding author for this work

Department of Mechanical and Aerospace Engineering

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

4 Citations (Scopus)

Abstract

This paper describes a comparative study of two feedback control methods for a microfluidic electroporation (EP) system. The regulation of the transmembrane voltage (V_m) and nano-electropore radius (r) of HeLa cells on a micro EP chip was achieved using a linear Proportional-Integral- Derivative (PID) Controller and also Model Predictive Controller (MPC) based on the critical electric field for single-cell EP. Numerical simulations of static and dynamic responses of the two critical states, V_m and r, shows that feedback control can improve the cell viability and EP efficiency compared to open-loop (OL) system. The benefits and limitations of these two control methods for EP and possible future works have also been discussed.

Original language	English
Title of host publication	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Pages	895-898
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2013.6559867
Publication status	Published - 2013
Event	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China Duration: 7 Apr 2013 → 10 Apr 2013

Publication series

Name	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013

Conference

Conference	8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Country/Territory	China
City	Suzhou
Period	7/04/13 → 10/04/13

Keywords

Feedback Control
MPC
Micro EP
PID

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10.1109/NEMS.2013.6559867

Cite this

Ghadami, M., Shagoshtasbi, H., Mahjoob, M. J., & Lee, Y. K. (2013). Comparative study of PID control and model predictive control for a microfluidic electroporation system. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 (pp. 895-898). Article 6559867 (8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013). https://doi.org/10.1109/NEMS.2013.6559867

Ghadami, M. ; Shagoshtasbi, H. ; Mahjoob, M. J. et al. / Comparative study of PID control and model predictive control for a microfluidic electroporation system. 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013. 2013. pp. 895-898 (8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013).

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title = "Comparative study of PID control and model predictive control for a microfluidic electroporation system",

abstract = "This paper describes a comparative study of two feedback control methods for a microfluidic electroporation (EP) system. The regulation of the transmembrane voltage (Vm) and nano-electropore radius (r) of HeLa cells on a micro EP chip was achieved using a linear Proportional-Integral- Derivative (PID) Controller and also Model Predictive Controller (MPC) based on the critical electric field for single-cell EP. Numerical simulations of static and dynamic responses of the two critical states, Vm and r, shows that feedback control can improve the cell viability and EP efficiency compared to open-loop (OL) system. The benefits and limitations of these two control methods for EP and possible future works have also been discussed.",

keywords = "Feedback Control, MPC, Micro EP, PID",

author = "M. Ghadami and H. Shagoshtasbi and Mahjoob, \{M. J.\} and Lee, \{Y. K.\}",

year = "2013",

doi = "10.1109/NEMS.2013.6559867",

language = "English",

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pages = "895--898",

booktitle = "8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013",

note = "8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 ; Conference date: 07-04-2013 Through 10-04-2013",

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Ghadami, M, Shagoshtasbi, H, Mahjoob, MJ & Lee, YK 2013, Comparative study of PID control and model predictive control for a microfluidic electroporation system. in 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013., 6559867, 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013, pp. 895-898, 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013, Suzhou, China, 7/04/13. https://doi.org/10.1109/NEMS.2013.6559867

Comparative study of PID control and model predictive control for a microfluidic electroporation system. / Ghadami, M.; Shagoshtasbi, H.; Mahjoob, M. J. et al.
8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013. 2013. p. 895-898 6559867 (8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013).

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

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AU - Mahjoob, M. J.

AU - Lee, Y. K.

PY - 2013

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N2 - This paper describes a comparative study of two feedback control methods for a microfluidic electroporation (EP) system. The regulation of the transmembrane voltage (Vm) and nano-electropore radius (r) of HeLa cells on a micro EP chip was achieved using a linear Proportional-Integral- Derivative (PID) Controller and also Model Predictive Controller (MPC) based on the critical electric field for single-cell EP. Numerical simulations of static and dynamic responses of the two critical states, Vm and r, shows that feedback control can improve the cell viability and EP efficiency compared to open-loop (OL) system. The benefits and limitations of these two control methods for EP and possible future works have also been discussed.

AB - This paper describes a comparative study of two feedback control methods for a microfluidic electroporation (EP) system. The regulation of the transmembrane voltage (Vm) and nano-electropore radius (r) of HeLa cells on a micro EP chip was achieved using a linear Proportional-Integral- Derivative (PID) Controller and also Model Predictive Controller (MPC) based on the critical electric field for single-cell EP. Numerical simulations of static and dynamic responses of the two critical states, Vm and r, shows that feedback control can improve the cell viability and EP efficiency compared to open-loop (OL) system. The benefits and limitations of these two control methods for EP and possible future works have also been discussed.

KW - Feedback Control

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KW - Micro EP

KW - PID

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BT - 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013

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Ghadami M, Shagoshtasbi H, Mahjoob MJ, Lee YK. Comparative study of PID control and model predictive control for a microfluidic electroporation system. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013. 2013. p. 895-898. 6559867. (8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013). doi: 10.1109/NEMS.2013.6559867

Comparative study of PID control and model predictive control for a microfluidic electroporation system

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