Conventional and Unconventional Protein Secretion in Yeast and Animal Cells

Xiao Tang; Yusong Guo

doi:10.1007/978-1-0716-4059-3_1

Conventional and Unconventional Protein Secretion in Yeast and Animal Cells

Xiao Tang^*, Yusong Guo^*

^*Corresponding author for this work

Division of Life Science

Research output: Chapter in Book/Conference Proceeding/Report › Book Chapter › peer-review

Abstract

Protein secretion mediated by the secretory transport pathway is a sophisticated and highly regulated cellular process in eukaryotic cells. In the conventional secretory transport pathway, newly synthesized proteins pass through several endomembrane compartments to reach their destinations. This transport occurs via small, membrane-enclosed vesicles. To ensure the fidelity of trafficking, eukaryotic cells employ elaborate molecular machinery to accurately sort newly synthesized proteins into specific transport vesicles and precisely deliver them to respective acceptor compartments. Leaderless cargo proteins, lacking a signal peptide, follow an unconventional secretory pathway. This review encompasses the molecular machinery regulating both conventional and unconventional protein secretion in yeast and animal cells.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	1-17
Number of pages	17
DOIs	https://doi.org/10.1007/978-1-0716-4059-3_1
Publication status	Published - 2024

Publication series

Name	Methods in Molecular Biology
Volume	2841
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.

Keywords

Cargo adaptor
Cargo receptor
Protein secretion
Vesicle

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10.1007/978-1-0716-4059-3_1

Cite this

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title = "Conventional and Unconventional Protein Secretion in Yeast and Animal Cells",

abstract = "Protein secretion mediated by the secretory transport pathway is a sophisticated and highly regulated cellular process in eukaryotic cells. In the conventional secretory transport pathway, newly synthesized proteins pass through several endomembrane compartments to reach their destinations. This transport occurs via small, membrane-enclosed vesicles. To ensure the fidelity of trafficking, eukaryotic cells employ elaborate molecular machinery to accurately sort newly synthesized proteins into specific transport vesicles and precisely deliver them to respective acceptor compartments. Leaderless cargo proteins, lacking a signal peptide, follow an unconventional secretory pathway. This review encompasses the molecular machinery regulating both conventional and unconventional protein secretion in yeast and animal cells.",

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AU - Tang, Xiao

AU - Guo, Yusong

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.

PY - 2024

Y1 - 2024

N2 - Protein secretion mediated by the secretory transport pathway is a sophisticated and highly regulated cellular process in eukaryotic cells. In the conventional secretory transport pathway, newly synthesized proteins pass through several endomembrane compartments to reach their destinations. This transport occurs via small, membrane-enclosed vesicles. To ensure the fidelity of trafficking, eukaryotic cells employ elaborate molecular machinery to accurately sort newly synthesized proteins into specific transport vesicles and precisely deliver them to respective acceptor compartments. Leaderless cargo proteins, lacking a signal peptide, follow an unconventional secretory pathway. This review encompasses the molecular machinery regulating both conventional and unconventional protein secretion in yeast and animal cells.

AB - Protein secretion mediated by the secretory transport pathway is a sophisticated and highly regulated cellular process in eukaryotic cells. In the conventional secretory transport pathway, newly synthesized proteins pass through several endomembrane compartments to reach their destinations. This transport occurs via small, membrane-enclosed vesicles. To ensure the fidelity of trafficking, eukaryotic cells employ elaborate molecular machinery to accurately sort newly synthesized proteins into specific transport vesicles and precisely deliver them to respective acceptor compartments. Leaderless cargo proteins, lacking a signal peptide, follow an unconventional secretory pathway. This review encompasses the molecular machinery regulating both conventional and unconventional protein secretion in yeast and animal cells.

KW - Cargo adaptor

KW - Cargo receptor

KW - Protein secretion

KW - Vesicle

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UR - https://www.scopus.com/pages/publications/85200939557

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DO - 10.1007/978-1-0716-4059-3_1

M3 - Book Chapter

T3 - Methods in Molecular Biology

SP - 1

EP - 17

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Conventional and Unconventional Protein Secretion in Yeast and Animal Cells

Abstract

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Bibliographical note

Keywords

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