Dammarane saponins from Gynostemma pentaphyllum

Yongmei Hu; Fanny C.F. Ip; Guangmiao Fu; Haihong Pang; Wencai Ye; Nancy Y. Ip

doi:10.1016/j.phytochem.2010.04.003

Dammarane saponins from Gynostemma pentaphyllum

Yongmei Hu, Fanny C.F. Ip, Guangmiao Fu, Haihong Pang, Wencai Ye, Nancy Y. Ip

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Abstract

Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4, 6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7.

Original language	English
Pages (from-to)	1149-1157
Number of pages	9
Journal	Phytochemistry
Volume	71
Issue number	10
DOIs	https://doi.org/10.1016/j.phytochem.2010.04.003
Publication status	Published - Jul 2010

Keywords

Cortical neurons
Cucurbitaceae
ERK phosphorylation
Gynostemma pentaphyllum
Saponins

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10.1016/j.phytochem.2010.04.003

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title = "Dammarane saponins from Gynostemma pentaphyllum",

abstract = "Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4, 6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7.",

keywords = "Cortical neurons, Cucurbitaceae, ERK phosphorylation, Gynostemma pentaphyllum, Saponins",

author = "Yongmei Hu and Ip, \{Fanny C.F.\} and Guangmiao Fu and Haihong Pang and Wencai Ye and Ip, \{Nancy Y.\}",

year = "2010",

month = jul,

doi = "10.1016/j.phytochem.2010.04.003",

language = "English",

volume = "71",

pages = "1149--1157",

journal = "Phytochemistry",

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TY - JOUR

T1 - Dammarane saponins from Gynostemma pentaphyllum

AU - Hu, Yongmei

AU - Ip, Fanny C.F.

AU - Fu, Guangmiao

AU - Pang, Haihong

AU - Ye, Wencai

AU - Ip, Nancy Y.

PY - 2010/7

Y1 - 2010/7

N2 - Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4, 6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7.

AB - Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4, 6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7.

KW - Cortical neurons

KW - Cucurbitaceae

KW - ERK phosphorylation

KW - Gynostemma pentaphyllum

KW - Saponins

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000279412900013

UR - https://openalex.org/W2017284304

UR - https://www.scopus.com/pages/publications/77954214798

U2 - 10.1016/j.phytochem.2010.04.003

DO - 10.1016/j.phytochem.2010.04.003

M3 - Journal Article

C2 - 20483436

SN - 0031-9422

VL - 71

SP - 1149

EP - 1157

JO - Phytochemistry

JF - Phytochemistry

IS - 10

ER -

Dammarane saponins from Gynostemma pentaphyllum

Abstract

Keywords

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