TY - JOUR
T1 - Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.
AU - Matsui, H.
AU - Itano, T.
AU - Etoh, S.
AU - Tokuda, M.
AU - Wang, J. H.
AU - Hatase, O.
PY - 1989
Y1 - 1989
N2 - Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
AB - Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
UR - http://www.scopus.com/inward/record.url?scp=0024846803&partnerID=8YFLogxK
U2 - 10.1007/978-1-4684-5679-0_40
DO - 10.1007/978-1-4684-5679-0_40
M3 - Journal Article
C2 - 2559600
AN - SCOPUS:0024846803
SN - 0065-2598
VL - 255
SP - 369
EP - 375
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -