TY - JOUR
T1 - Differentiation-Defective Stem Cells Outcompete Normal Stem Cells for Niche Occupancy in the Drosophila Ovary
AU - Jin, Zhigang
AU - Kirilly, Daniel
AU - Weng, Changjiang
AU - Kawase, Eihachiro
AU - Song, Xiaoqing
AU - Smith, Sarah
AU - Schwartz, Joel
AU - Xie, Ting
PY - 2008/1/10
Y1 - 2008/1/10
N2 - Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche occupancy in a cadherin-dependent manner. The differentiation-defective bam or bgcn mutant GSCs invade the niche space of neighboring wild-type GSCs and gradually push them out of the niche by upregulating E-cadherin expression. Furthermore, the bam/bgcn-mediated GSC competition requires E-cadherin and normal GSC division, but not the self-renewal-promoting BMP niche signal, while different E-cadherin levels can sufficiently stimulate GSC competition. Therefore, we propose that GSCs have a competitive relationship for niche occupancy, which may serve as a quality control mechanism to ensure that accidentally differentiated stem cells are rapidly removed from the niche and replaced by functional ones.
AB - Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche occupancy in a cadherin-dependent manner. The differentiation-defective bam or bgcn mutant GSCs invade the niche space of neighboring wild-type GSCs and gradually push them out of the niche by upregulating E-cadherin expression. Furthermore, the bam/bgcn-mediated GSC competition requires E-cadherin and normal GSC division, but not the self-renewal-promoting BMP niche signal, while different E-cadherin levels can sufficiently stimulate GSC competition. Therefore, we propose that GSCs have a competitive relationship for niche occupancy, which may serve as a quality control mechanism to ensure that accidentally differentiated stem cells are rapidly removed from the niche and replaced by functional ones.
KW - STEMCELL
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000252606400010
UR - https://openalex.org/W2098092642
UR - https://www.scopus.com/pages/publications/37549000504
U2 - 10.1016/j.stem.2007.10.021
DO - 10.1016/j.stem.2007.10.021
M3 - Journal Article
C2 - 18371420
SN - 1934-5909
VL - 2
SP - 39
EP - 49
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 1
ER -