DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy

Zeyu Xiao; Changwei Ji; Jinjun Shi; Eric M. Pridgen; Jillian Frieder; Jun Wu; Omid C. Farokhzad

doi:10.1002/anie.201204018

DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy

Zeyu Xiao^*
, Changwei Ji
, Jinjun Shi
, Eric M. Pridgen
, Jillian Frieder
, Jun Wu
, Omid C. Farokhzad

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

336 Citations (Scopus)

Abstract

Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy invitro and invivo.

Original language	English
Pages (from-to)	11853-11857
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	47
DOIs	https://doi.org/10.1002/anie.201204018
Publication status	Published - 19 Nov 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA
cancer
drug delivery
nanorods
near-infrared light

Access to Document

10.1002/anie.201204018

Cite this

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title = "DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy",

abstract = "Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy invitro and invivo.",

keywords = "DNA, cancer, drug delivery, nanorods, near-infrared light",

author = "Zeyu Xiao and Changwei Ji and Jinjun Shi and Pridgen, \{Eric M.\} and Jillian Frieder and Jun Wu and Farokhzad, \{Omid C.\}",

year = "2012",

month = nov,

day = "19",

doi = "10.1002/anie.201204018",

language = "English",

volume = "51",

pages = "11853--11857",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "47",

}

TY - JOUR

T1 - DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy

AU - Xiao, Zeyu

AU - Ji, Changwei

AU - Shi, Jinjun

AU - Pridgen, Eric M.

AU - Frieder, Jillian

AU - Wu, Jun

AU - Farokhzad, Omid C.

PY - 2012/11/19

Y1 - 2012/11/19

N2 - Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy invitro and invivo.

AB - Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy invitro and invivo.

KW - DNA

KW - cancer

KW - drug delivery

KW - nanorods

KW - near-infrared light

UR - https://openalex.org/W2118291545

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000311702000038

U2 - 10.1002/anie.201204018

DO - 10.1002/anie.201204018

M3 - Journal Article

C2 - 23081716

SN - 1433-7851

VL - 51

SP - 11853

EP - 11857

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 47

ER -

DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy

Abstract

UN SDGs

Keywords

Access to Document

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