End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation

Salvatore Mascia; Patrick L. Heider; Haitao Zhang; Richard Lakerveld; Brahim Benyahia; Paul I. Barton; Richard D. Braatz; Charles L. Cooney; James M.B. Evans; Timothy F. Jamison; Klavs F. Jensen; Allan S. Myerson; Bernhardt L. Trout

doi:10.1002/anie.201305429

End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation

Salvatore Mascia
, Patrick L. Heider
, Haitao Zhang
, Richard Lakerveld
, Brahim Benyahia
, Paul I. Barton
, Richard D. Braatz
, Charles L. Cooney
, James M.B. Evans
, Timothy F. Jamison
, Klavs F. Jensen
, Allan S. Myerson
, Bernhardt L. Trout

Research output: Contribution to journal › Journal Article › peer-review

589 Citations (Scopus)

Abstract

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.

Original language	English
Pages (from-to)	12359-12363
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	47
DOIs	https://doi.org/10.1002/anie.201305429
Publication status	Published - 18 Nov 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

continuous processing
flow chemistry
lactones
protecting groups
synthetic methods

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10.1002/anie.201305429

Cite this

Mascia, S., Heider, P. L., Zhang, H., Lakerveld, R., Benyahia, B., Barton, P. I., Braatz, R. D., Cooney, C. L., Evans, J. M. B., Jamison, T. F., Jensen, K. F., Myerson, A. S., & Trout, B. L. (2013). End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation. Angewandte Chemie - International Edition, 52(47), 12359-12363. https://doi.org/10.1002/anie.201305429

@article{5697f95a0fb84ad3b900b63e74a1cb73,

title = "End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation",

abstract = "A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.",

keywords = "continuous processing, flow chemistry, lactones, protecting groups, synthetic methods",

author = "Salvatore Mascia and Heider, \{Patrick L.\} and Haitao Zhang and Richard Lakerveld and Brahim Benyahia and Barton, \{Paul I.\} and Braatz, \{Richard D.\} and Cooney, \{Charles L.\} and Evans, \{James M.B.\} and Jamison, \{Timothy F.\} and Jensen, \{Klavs F.\} and Myerson, \{Allan S.\} and Trout, \{Bernhardt L.\}",

year = "2013",

month = nov,

day = "18",

doi = "10.1002/anie.201305429",

language = "English",

volume = "52",

pages = "12359--12363",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "47",

}

Mascia, S, Heider, PL, Zhang, H, Lakerveld, R, Benyahia, B, Barton, PI, Braatz, RD, Cooney, CL, Evans, JMB, Jamison, TF, Jensen, KF, Myerson, AS & Trout, BL 2013, 'End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation', Angewandte Chemie - International Edition, vol. 52, no. 47, pp. 12359-12363. https://doi.org/10.1002/anie.201305429

TY - JOUR

T1 - End-to-end continuous manufacturing of pharmaceuticals

T2 - Integrated synthesis, purification, and final dosage formation

AU - Mascia, Salvatore

AU - Heider, Patrick L.

AU - Zhang, Haitao

AU - Lakerveld, Richard

AU - Benyahia, Brahim

AU - Barton, Paul I.

AU - Braatz, Richard D.

AU - Cooney, Charles L.

AU - Evans, James M.B.

AU - Jamison, Timothy F.

AU - Jensen, Klavs F.

AU - Myerson, Allan S.

AU - Trout, Bernhardt L.

PY - 2013/11/18

Y1 - 2013/11/18

N2 - A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.

AB - A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.

KW - continuous processing

KW - flow chemistry

KW - lactones

KW - protecting groups

KW - synthetic methods

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000326807900031

UR - https://openalex.org/W2112211764

U2 - 10.1002/anie.201305429

DO - 10.1002/anie.201305429

M3 - Journal Article

C2 - 24115355

SN - 1433-7851

VL - 52

SP - 12359

EP - 12363

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 47

ER -

End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation

Abstract

UN SDGs

Keywords

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