Enzymatic formation of supramolecular hydrogels

Zhimou Yang; Hongwei Gu; Degang Fu; Ping Gao; Jing Kwok Lam; Bing Xu

doi:10.1002/adma.200400340

Enzymatic formation of supramolecular hydrogels

Zhimou Yang^*, Hongwei Gu, Degang Fu, Ping Gao, Jing Kwok Lam, Bing Xu

^*Corresponding author for this work

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Journal Article › peer-review

579 Citations (Scopus)

Abstract

The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.

Original language	English
Pages (from-to)	1440-1444
Number of pages	5
Journal	Advanced Materials
Volume	16
Issue number	16
DOIs	https://doi.org/10.1002/adma.200400340
Publication status	Published - 18 Aug 2004

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10.1002/adma.200400340

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title = "Enzymatic formation of supramolecular hydrogels",

abstract = "The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.",

author = "Zhimou Yang and Hongwei Gu and Degang Fu and Ping Gao and Lam, \{Jing Kwok\} and Bing Xu",

year = "2004",

month = aug,

day = "18",

doi = "10.1002/adma.200400340",

language = "English",

volume = "16",

pages = "1440--1444",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Enzymatic formation of supramolecular hydrogels

AU - Yang, Zhimou

AU - Gu, Hongwei

AU - Fu, Degang

AU - Gao, Ping

AU - Lam, Jing Kwok

AU - Xu, Bing

PY - 2004/8/18

Y1 - 2004/8/18

N2 - The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.

AB - The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000223933700012

UR - https://www.scopus.com/pages/publications/19444371972

U2 - 10.1002/adma.200400340

DO - 10.1002/adma.200400340

M3 - Journal Article

SN - 0935-9648

VL - 16

SP - 1440

EP - 1444

JO - Advanced Materials

JF - Advanced Materials

IS - 16

ER -

Enzymatic formation of supramolecular hydrogels

Abstract

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