Flipping APOE to reverse Alzheimer’s disease traits

Jeff Y.L. Lam; Kai Wang; Guojun Bu

doi:10.1038/s41593-025-02108-9

Flipping APOE to reverse Alzheimer’s disease traits

Jeff Y.L. Lam, Kai Wang, Guojun Bu^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo ‘switching’ from the Alzheimer’s risk gene APOE4 to the protective gene APOE2. This genetic conversion reshapes Alzheimer’s disease-related metabolism, reduces neuropathology, and enhances cognition, demonstrating the beneficial effects of APOE genetic targeting as a promising therapeutic strategy.

Original language	English
Pages (from-to)	2407-2409
Journal	Nature Neuroscience
DOIs	https://doi.org/10.1038/s41593-025-02108-9
Publication status	Published - 11 Nov 2025

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© Springer Nature America, Inc. 2025.

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abstract = "In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo {\textquoteleft}switching{\textquoteright} from the Alzheimer{\textquoteright}s risk gene APOE4 to the protective gene APOE2. This genetic conversion reshapes Alzheimer{\textquoteright}s disease-related metabolism, reduces neuropathology, and enhances cognition, demonstrating the beneficial effects of APOE genetic targeting as a promising therapeutic strategy.",

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AB - In this issue of Nature Neuroscience, Golden et al. unveil a mouse model that enables in vivo ‘switching’ from the Alzheimer’s risk gene APOE4 to the protective gene APOE2. This genetic conversion reshapes Alzheimer’s disease-related metabolism, reduces neuropathology, and enhances cognition, demonstrating the beneficial effects of APOE genetic targeting as a promising therapeutic strategy.

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Flipping APOE to reverse Alzheimer’s disease traits

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