Genomic integrity and the ageing brain

Hei Man Chow; Karl Herrup

doi:10.1038/nrn4020

Genomic integrity and the ageing brain

Hei Man Chow
, Karl Herrup^*

^*Corresponding author for this work

Division of Life Science

Research output: Contribution to journal › Review article › peer-review

149 Citations (Scopus)

Abstract

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.

Original language	English
Pages (from-to)	672-684
Number of pages	13
Journal	Nature Reviews Neuroscience
Volume	16
Issue number	11
DOIs	https://doi.org/10.1038/nrn4020
Publication status	Published - 1 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 Macmillan Publishers Limited.

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10.1038/nrn4020

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abstract = "DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.",

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AB - DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.

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Genomic integrity and the ageing brain

Abstract

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