Homer Tetramer Promotes Actin Bundling Activity of Drebrin

Zhiwei Li; Haiyang Liu; Jianchao Li; Qingqing Yang; Zhe Feng; Yujie Li; Haibin Yang; Cong Yu; Jun Wan; Wei Liu; Mingjie Zhang

doi:10.1016/j.str.2018.10.011

Homer Tetramer Promotes Actin Bundling Activity of Drebrin

Zhiwei Li
, Haiyang Liu
, Jianchao Li
, Qingqing Yang
, Zhe Feng
, Yujie Li
, Haibin Yang
, Cong Yu
, Jun Wan
, Wei Liu^*
, Mingjie Zhang

^*Corresponding author for this work

Division of Life Science

Research output: Contribution to journal › Journal Article › peer-review

23 Citations (Scopus)

Abstract

The crystal structure of Drebrin-HBM1/Homer-EVH1 reveals an extended Homer EVH1 binding motif. Homer tetramer promotes actin bundling activity of Drebrin and stimulates Drebrin-induced filopodia formation in cells, suggesting a potential role of Homer1 in modulating synaptic spine homeostatic scaling via binding to Drebrin.

Original language	English
Pages (from-to)	27-38.e4
Journal	Structure
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.str.2018.10.011
Publication status	Published - 2 Jan 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Drebrin
EVH1 domain
Homer1
actin bundle
postsynaptic density
proline rich motif
scaffold proteins
synaptic plasticity

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10.1016/j.str.2018.10.011

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@article{89a31fb0bb19451d88055ab6fd87337e,

title = "Homer Tetramer Promotes Actin Bundling Activity of Drebrin",

abstract = "The crystal structure of Drebrin-HBM1/Homer-EVH1 reveals an extended Homer EVH1 binding motif. Homer tetramer promotes actin bundling activity of Drebrin and stimulates Drebrin-induced filopodia formation in cells, suggesting a potential role of Homer1 in modulating synaptic spine homeostatic scaling via binding to Drebrin.",

keywords = "Drebrin, EVH1 domain, Homer1, actin bundle, postsynaptic density, proline rich motif, scaffold proteins, synaptic plasticity",

author = "Zhiwei Li and Haiyang Liu and Jianchao Li and Qingqing Yang and Zhe Feng and Yujie Li and Haibin Yang and Cong Yu and Jun Wan and Wei Liu and Mingjie Zhang",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

day = "2",

doi = "10.1016/j.str.2018.10.011",

language = "English",

volume = "27",

pages = "27--38.e4",

journal = "Structure",

issn = "0969-2126",

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}

TY - JOUR

T1 - Homer Tetramer Promotes Actin Bundling Activity of Drebrin

AU - Li, Zhiwei

AU - Liu, Haiyang

AU - Li, Jianchao

AU - Yang, Qingqing

AU - Feng, Zhe

AU - Li, Yujie

AU - Yang, Haibin

AU - Yu, Cong

AU - Wan, Jun

AU - Liu, Wei

AU - Zhang, Mingjie

PY - 2019/1/2

Y1 - 2019/1/2

N2 - The crystal structure of Drebrin-HBM1/Homer-EVH1 reveals an extended Homer EVH1 binding motif. Homer tetramer promotes actin bundling activity of Drebrin and stimulates Drebrin-induced filopodia formation in cells, suggesting a potential role of Homer1 in modulating synaptic spine homeostatic scaling via binding to Drebrin.

AB - The crystal structure of Drebrin-HBM1/Homer-EVH1 reveals an extended Homer EVH1 binding motif. Homer tetramer promotes actin bundling activity of Drebrin and stimulates Drebrin-induced filopodia formation in cells, suggesting a potential role of Homer1 in modulating synaptic spine homeostatic scaling via binding to Drebrin.

KW - Drebrin

KW - EVH1 domain

KW - Homer1

KW - actin bundle

KW - postsynaptic density

KW - proline rich motif

KW - scaffold proteins

KW - synaptic plasticity

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000454804900004

UR - https://openalex.org/W2902652212

U2 - 10.1016/j.str.2018.10.011

DO - 10.1016/j.str.2018.10.011

M3 - Journal Article

SN - 0969-2126

VL - 27

SP - 27-38.e4

JO - Structure

JF - Structure

IS - 1

ER -

Homer Tetramer Promotes Actin Bundling Activity of Drebrin

Abstract

Bibliographical note

Keywords

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