In vitro examination of the pressure effect on clot dissolution with thrombolytic patch

Zhen Qin; Chi Hang Chon; John C.K. Kwok; David C.C. Lam

doi:10.1109/EMBC.2016.7590761

In vitro examination of the pressure effect on clot dissolution with thrombolytic patch

Zhen Qin, Chi Hang Chon, John C.K. Kwok, David C.C. Lam

Department of Mechanical and Aerospace Engineering

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

Abstract

Bio-kinetic thrombus dissolution model has been developed to describe the thrombus dissolution behavior during endoluminal thrombolytic patch treatment to recanalize blocked vessel in ischemic strokes. The initial model ignored the effect of pulsatile pressure in the lumen. However, pulsatile pressure in the lumen may affect molecule diffusion and bio-chemical reaction rate and accelerate clot dissolution. The effect of pressure on the dissolution rate was examined in this study. The dissolution behaviors of 100-400 μm thick blood clot specimens subject to diastolic, systolic, and pulsatile pressure were characterized using Raman spectroscopy. The results showed that dissolution time was reduced by less than 2 mins and is negligible in comparison with total treatment time. The effect of pressure may be ignored and the developed bio-kinetic model may be used in surgical applications of endoluminal thrombolytic patch to estimate treatment time in ischemic stroke.

Original language	English
Title of host publication	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	549-552
Number of pages	4
ISBN (Electronic)	9781457702204
DOIs	https://doi.org/10.1109/EMBC.2016.7590761
Publication status	Published - 13 Oct 2016
Event	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: 16 Aug 2016 → 20 Aug 2016

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2016-October
ISSN (Print)	1557-170X

Conference

Conference	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Country/Territory	United States
City	Orlando
Period	16/08/16 → 20/08/16

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/EMBC.2016.7590761

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Qin, Z., Chon, C. H., Kwok, J. C. K., & Lam, D. C. C. (2016). In vitro examination of the pressure effect on clot dissolution with thrombolytic patch. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (pp. 549-552). Article 7590761 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7590761

Qin, Zhen ; Chon, Chi Hang ; Kwok, John C.K. et al. / In vitro examination of the pressure effect on clot dissolution with thrombolytic patch. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 549-552 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "In vitro examination of the pressure effect on clot dissolution with thrombolytic patch",

abstract = "Bio-kinetic thrombus dissolution model has been developed to describe the thrombus dissolution behavior during endoluminal thrombolytic patch treatment to recanalize blocked vessel in ischemic strokes. The initial model ignored the effect of pulsatile pressure in the lumen. However, pulsatile pressure in the lumen may affect molecule diffusion and bio-chemical reaction rate and accelerate clot dissolution. The effect of pressure on the dissolution rate was examined in this study. The dissolution behaviors of 100-400 μm thick blood clot specimens subject to diastolic, systolic, and pulsatile pressure were characterized using Raman spectroscopy. The results showed that dissolution time was reduced by less than 2 mins and is negligible in comparison with total treatment time. The effect of pressure may be ignored and the developed bio-kinetic model may be used in surgical applications of endoluminal thrombolytic patch to estimate treatment time in ischemic stroke.",

author = "Zhen Qin and Chon, \{Chi Hang\} and Kwok, \{John C.K.\} and Lam, \{David C.C.\}",

note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 ; Conference date: 16-08-2016 Through 20-08-2016",

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Qin, Z, Chon, CH, Kwok, JCK & Lam, DCC 2016, In vitro examination of the pressure effect on clot dissolution with thrombolytic patch. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016., 7590761, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2016-October, Institute of Electrical and Electronics Engineers Inc., pp. 549-552, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, United States, 16/08/16. https://doi.org/10.1109/EMBC.2016.7590761

In vitro examination of the pressure effect on clot dissolution with thrombolytic patch. / Qin, Zhen; Chon, Chi Hang; Kwok, John C.K. et al.
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 549-552 7590761 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October).

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

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N2 - Bio-kinetic thrombus dissolution model has been developed to describe the thrombus dissolution behavior during endoluminal thrombolytic patch treatment to recanalize blocked vessel in ischemic strokes. The initial model ignored the effect of pulsatile pressure in the lumen. However, pulsatile pressure in the lumen may affect molecule diffusion and bio-chemical reaction rate and accelerate clot dissolution. The effect of pressure on the dissolution rate was examined in this study. The dissolution behaviors of 100-400 μm thick blood clot specimens subject to diastolic, systolic, and pulsatile pressure were characterized using Raman spectroscopy. The results showed that dissolution time was reduced by less than 2 mins and is negligible in comparison with total treatment time. The effect of pressure may be ignored and the developed bio-kinetic model may be used in surgical applications of endoluminal thrombolytic patch to estimate treatment time in ischemic stroke.

AB - Bio-kinetic thrombus dissolution model has been developed to describe the thrombus dissolution behavior during endoluminal thrombolytic patch treatment to recanalize blocked vessel in ischemic strokes. The initial model ignored the effect of pulsatile pressure in the lumen. However, pulsatile pressure in the lumen may affect molecule diffusion and bio-chemical reaction rate and accelerate clot dissolution. The effect of pressure on the dissolution rate was examined in this study. The dissolution behaviors of 100-400 μm thick blood clot specimens subject to diastolic, systolic, and pulsatile pressure were characterized using Raman spectroscopy. The results showed that dissolution time was reduced by less than 2 mins and is negligible in comparison with total treatment time. The effect of pressure may be ignored and the developed bio-kinetic model may be used in surgical applications of endoluminal thrombolytic patch to estimate treatment time in ischemic stroke.

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Qin Z, Chon CH, Kwok JCK, Lam DCC. In vitro examination of the pressure effect on clot dissolution with thrombolytic patch. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 549-552. 7590761. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2016.7590761

In vitro examination of the pressure effect on clot dissolution with thrombolytic patch

Abstract

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Bibliographical note

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