In vivo antioxidant mechanism of 'Sheng Mai San', a compound formulation

P. K. Yick; M. K.T. Poon; S. P. Ip; K. M. Ko

doi:10.1076/phbi.36.3.189.6342

In vivo antioxidant mechanism of 'Sheng Mai San', a compound formulation

P. K. Yick
, M. K.T. Poon
, S. P. Ip
, K. M. Ko^*

^*Corresponding author for this work

Division of Life Science

Research output: Contribution to journal › Journal Article › peer-review

4 Citations (Scopus)

Abstract

The in vivo antioxidant mechanism of Sheng Mai San (SMS), a compound formulation in traditional Chinese medicine comprising Panax ginseng, Schisandra chinensis and Ophiopogon japonicus, was investigated using a rat model of CCl₄ hepatotoxicity. SMS-crude extract and its aqueous or chloroform fraction were found to protect against CCl₄-induced hepatotoxicity. The hepatoprotection afforded by SMS or its fraction pretreatment was associated with an enhanced hepatic glutathione (GSH) status, as indicated by increases in hepatic GSH levels and glucose-6-phosphate dehydrogenase activities, as well as a decrease in susceptibility of hepatic homogenates to peroxide-induced GSH depletion. These results suggest that the in vivo antioxidant mechanism of SMS may involve the facilitation of hepatic GSH regeneration under increased oxidative stress conditions.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	Pharmaceutical Biology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1076/phbi.36.3.189.6342
Publication status	Published - 1998

Keywords

Carbon tetrachloride
Glutathione
Ophiopogon japonicus
Panax ginseng
Schisandra chinensis

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10.1076/phbi.36.3.189.6342

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title = "In vivo antioxidant mechanism of 'Sheng Mai San', a compound formulation",

abstract = "The in vivo antioxidant mechanism of Sheng Mai San (SMS), a compound formulation in traditional Chinese medicine comprising Panax ginseng, Schisandra chinensis and Ophiopogon japonicus, was investigated using a rat model of CCl4 hepatotoxicity. SMS-crude extract and its aqueous or chloroform fraction were found to protect against CCl4-induced hepatotoxicity. The hepatoprotection afforded by SMS or its fraction pretreatment was associated with an enhanced hepatic glutathione (GSH) status, as indicated by increases in hepatic GSH levels and glucose-6-phosphate dehydrogenase activities, as well as a decrease in susceptibility of hepatic homogenates to peroxide-induced GSH depletion. These results suggest that the in vivo antioxidant mechanism of SMS may involve the facilitation of hepatic GSH regeneration under increased oxidative stress conditions.",

keywords = "Carbon tetrachloride, Glutathione, Ophiopogon japonicus, Panax ginseng, Schisandra chinensis",

author = "Yick, \{P. K.\} and Poon, \{M. K.T.\} and Ip, \{S. P.\} and Ko, \{K. M.\}",

year = "1998",

doi = "10.1076/phbi.36.3.189.6342",

language = "English",

volume = "36",

pages = "189--193",

journal = "Pharmaceutical Biology",

issn = "1388-0209",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - In vivo antioxidant mechanism of 'Sheng Mai San', a compound formulation

AU - Yick, P. K.

AU - Poon, M. K.T.

AU - Ip, S. P.

AU - Ko, K. M.

PY - 1998

Y1 - 1998

N2 - The in vivo antioxidant mechanism of Sheng Mai San (SMS), a compound formulation in traditional Chinese medicine comprising Panax ginseng, Schisandra chinensis and Ophiopogon japonicus, was investigated using a rat model of CCl4 hepatotoxicity. SMS-crude extract and its aqueous or chloroform fraction were found to protect against CCl4-induced hepatotoxicity. The hepatoprotection afforded by SMS or its fraction pretreatment was associated with an enhanced hepatic glutathione (GSH) status, as indicated by increases in hepatic GSH levels and glucose-6-phosphate dehydrogenase activities, as well as a decrease in susceptibility of hepatic homogenates to peroxide-induced GSH depletion. These results suggest that the in vivo antioxidant mechanism of SMS may involve the facilitation of hepatic GSH regeneration under increased oxidative stress conditions.

AB - The in vivo antioxidant mechanism of Sheng Mai San (SMS), a compound formulation in traditional Chinese medicine comprising Panax ginseng, Schisandra chinensis and Ophiopogon japonicus, was investigated using a rat model of CCl4 hepatotoxicity. SMS-crude extract and its aqueous or chloroform fraction were found to protect against CCl4-induced hepatotoxicity. The hepatoprotection afforded by SMS or its fraction pretreatment was associated with an enhanced hepatic glutathione (GSH) status, as indicated by increases in hepatic GSH levels and glucose-6-phosphate dehydrogenase activities, as well as a decrease in susceptibility of hepatic homogenates to peroxide-induced GSH depletion. These results suggest that the in vivo antioxidant mechanism of SMS may involve the facilitation of hepatic GSH regeneration under increased oxidative stress conditions.

KW - Carbon tetrachloride

KW - Glutathione

KW - Ophiopogon japonicus

KW - Panax ginseng

KW - Schisandra chinensis

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000077911500006

UR - https://openalex.org/W2086944485

U2 - 10.1076/phbi.36.3.189.6342

DO - 10.1076/phbi.36.3.189.6342

M3 - Journal Article

SN - 1388-0209

VL - 36

SP - 189

EP - 193

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

IS - 3

ER -

In vivo antioxidant mechanism of 'Sheng Mai San', a compound formulation

Abstract

Keywords

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