TY - JOUR
T1 - In vivo antioxidant mechanism of 'Sheng Mai San', a compound formulation
AU - Yick, P. K.
AU - Poon, M. K.T.
AU - Ip, S. P.
AU - Ko, K. M.
PY - 1998
Y1 - 1998
N2 - The in vivo antioxidant mechanism of Sheng Mai San (SMS), a compound formulation in traditional Chinese medicine comprising Panax ginseng, Schisandra chinensis and Ophiopogon japonicus, was investigated using a rat model of CCl4 hepatotoxicity. SMS-crude extract and its aqueous or chloroform fraction were found to protect against CCl4-induced hepatotoxicity. The hepatoprotection afforded by SMS or its fraction pretreatment was associated with an enhanced hepatic glutathione (GSH) status, as indicated by increases in hepatic GSH levels and glucose-6-phosphate dehydrogenase activities, as well as a decrease in susceptibility of hepatic homogenates to peroxide-induced GSH depletion. These results suggest that the in vivo antioxidant mechanism of SMS may involve the facilitation of hepatic GSH regeneration under increased oxidative stress conditions.
AB - The in vivo antioxidant mechanism of Sheng Mai San (SMS), a compound formulation in traditional Chinese medicine comprising Panax ginseng, Schisandra chinensis and Ophiopogon japonicus, was investigated using a rat model of CCl4 hepatotoxicity. SMS-crude extract and its aqueous or chloroform fraction were found to protect against CCl4-induced hepatotoxicity. The hepatoprotection afforded by SMS or its fraction pretreatment was associated with an enhanced hepatic glutathione (GSH) status, as indicated by increases in hepatic GSH levels and glucose-6-phosphate dehydrogenase activities, as well as a decrease in susceptibility of hepatic homogenates to peroxide-induced GSH depletion. These results suggest that the in vivo antioxidant mechanism of SMS may involve the facilitation of hepatic GSH regeneration under increased oxidative stress conditions.
KW - Carbon tetrachloride
KW - Glutathione
KW - Ophiopogon japonicus
KW - Panax ginseng
KW - Schisandra chinensis
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000077911500006
UR - https://openalex.org/W2086944485
UR - https://www.scopus.com/pages/publications/0032428315
U2 - 10.1076/phbi.36.3.189.6342
DO - 10.1076/phbi.36.3.189.6342
M3 - Journal Article
SN - 1388-0209
VL - 36
SP - 189
EP - 193
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 3
ER -