In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

Li Lin; Jun Xia; Terence T.W. Wong; Ruiying Zhang; Lihong V. Wang

doi:10.1117/12.2076482

In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

Li Lin, Jun Xia, Terence T.W. Wong, Ruiying Zhang, Lihong V. Wang^*

^*Corresponding author for this work

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

4 Citations (Scopus)

Abstract

We demonstrate, by means of internal light delivery, photoacoustic imaging of the deep brain of rats in vivo. With fiber illumination via the oral cavity, we delivered light directly into the bottom of the brain, much more than can be delivered by external illumination. The study was performed using a photoacoustic computed tomography (PACT) system equipped with a 512-element full-ring transducer array, providing a full two-dimensional view aperture. Using internal illumination, the PACT system provided clear cross sectional photoacoustic images from the palate to the middle brain of live rats, revealing deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2015
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781628414134
DOIs	https://doi.org/10.1117/12.2076482
Publication status	Published - 11 Mar 2015
Externally published	Yes
Event	Photons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States Duration: 8 Feb 2015 → 10 Feb 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9323
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2015
Country/Territory	United States
City	San Francisco
Period	8/02/15 → 10/02/15

Bibliographical note

Publisher Copyright:
© 2015 SPIE.

Keywords

Deep brain imaging
Internal illumination
Optical fiber
Oral-cavity illumination
Photoacoustic computed tomography

Access to Document

10.1117/12.2076482

Cite this

Lin, L., Xia, J., Wong, T. T. W., Zhang, R., & Wang, L. V. (2015). In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2015 Article 93230G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323). SPIE. https://doi.org/10.1117/12.2076482

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title = "In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography",

abstract = "We demonstrate, by means of internal light delivery, photoacoustic imaging of the deep brain of rats in vivo. With fiber illumination via the oral cavity, we delivered light directly into the bottom of the brain, much more than can be delivered by external illumination. The study was performed using a photoacoustic computed tomography (PACT) system equipped with a 512-element full-ring transducer array, providing a full two-dimensional view aperture. Using internal illumination, the PACT system provided clear cross sectional photoacoustic images from the palate to the middle brain of live rats, revealing deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.",

keywords = "Deep brain imaging, Internal illumination, Optical fiber, Oral-cavity illumination, Photoacoustic computed tomography",

author = "Li Lin and Jun Xia and Wong, \{Terence T.W.\} and Ruiying Zhang and Wang, \{Lihong V.\}",

note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2015 ; Conference date: 08-02-2015 Through 10-02-2015",

year = "2015",

month = mar,

day = "11",

doi = "10.1117/12.2076482",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, \{Alexander A.\} and Wang, \{Lihong V.\}",

booktitle = "Photons Plus Ultrasound",

}

Lin, L, Xia, J, Wong, TTW, Zhang, R & Wang, LV 2015, In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2015., 93230G, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9323, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2015, San Francisco, United States, 8/02/15. https://doi.org/10.1117/12.2076482

In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography. / Lin, Li; Xia, Jun; Wong, Terence T.W. et al.
Photons Plus Ultrasound: Imaging and Sensing 2015. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2015. 93230G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323).

Research output: Chapter in Book/Conference Proceeding/Report › Conference Paper published in a book › peer-review

TY - GEN

T1 - In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

AU - Lin, Li

AU - Xia, Jun

AU - Wong, Terence T.W.

AU - Zhang, Ruiying

AU - Wang, Lihong V.

PY - 2015/3/11

Y1 - 2015/3/11

N2 - We demonstrate, by means of internal light delivery, photoacoustic imaging of the deep brain of rats in vivo. With fiber illumination via the oral cavity, we delivered light directly into the bottom of the brain, much more than can be delivered by external illumination. The study was performed using a photoacoustic computed tomography (PACT) system equipped with a 512-element full-ring transducer array, providing a full two-dimensional view aperture. Using internal illumination, the PACT system provided clear cross sectional photoacoustic images from the palate to the middle brain of live rats, revealing deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

AB - We demonstrate, by means of internal light delivery, photoacoustic imaging of the deep brain of rats in vivo. With fiber illumination via the oral cavity, we delivered light directly into the bottom of the brain, much more than can be delivered by external illumination. The study was performed using a photoacoustic computed tomography (PACT) system equipped with a 512-element full-ring transducer array, providing a full two-dimensional view aperture. Using internal illumination, the PACT system provided clear cross sectional photoacoustic images from the palate to the middle brain of live rats, revealing deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

KW - Deep brain imaging

KW - Internal illumination

KW - Optical fiber

KW - Oral-cavity illumination

KW - Photoacoustic computed tomography

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UR - https://openalex.org/W2175523182

UR - https://www.scopus.com/pages/publications/84928555078

U2 - 10.1117/12.2076482

DO - 10.1117/12.2076482

M3 - Conference Paper published in a book

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2015

Y2 - 8 February 2015 through 10 February 2015

ER -

In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

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