Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.

Yongxin Li; Shanjiang Yu; Dong Liu; Peter Proksch; Wenhan Lin

doi:10.1016/j.bmcl.2011.11.109

Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.

Yongxin Li, Shanjiang Yu, Dong Liu, Peter Proksch, Wenhan Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

60 Citations (Scopus)

Abstract

Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC ₅₀ values in a range of 3.45-9.03 μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed.

Original language	English
Pages (from-to)	1099-1102
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2011.11.109
Publication status	Published - 15 Jan 2012
Externally published	Yes

Keywords

Excoecaria agallocha L.
Excoecariphenols A-D
HCV RNA inhibition
Huh 7.5 cells
Mangrove plant
NS3-4A protein kinase inhibition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2011.11.109

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title = "Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.",

abstract = "Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC 50 values in a range of 3.45-9.03 μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed.",

keywords = "Excoecaria agallocha L., Excoecariphenols A-D, HCV RNA inhibition, Huh 7.5 cells, Mangrove plant, NS3-4A protein kinase inhibition",

author = "Yongxin Li and Shanjiang Yu and Dong Liu and Peter Proksch and Wenhan Lin",

year = "2012",

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doi = "10.1016/j.bmcl.2011.11.109",

language = "English",

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T1 - Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.

AU - Li, Yongxin

AU - Yu, Shanjiang

AU - Liu, Dong

AU - Proksch, Peter

AU - Lin, Wenhan

PY - 2012/1/15

Y1 - 2012/1/15

N2 - Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC 50 values in a range of 3.45-9.03 μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed.

AB - Four new polyphenols namely excoecariphenols A-D (1-4) were isolated from the Chinese mangrove plant Excoecaria agallocha L. together with 23 known phenolic compounds. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses including IR, MS, NMR, and CD data. Excoecariphenols A and B presented as the unusual flavane-based 1-thioglycosides. Part of the isolated polyphenols were tested against hepatitis C NS3-4A protease and HCV RNA in huh 7.5 cells. Excoecariphenol D, corilagin, geraniin, and chebulagic acid showed potential inhibition toward HCV NS3-4A protease with IC 50 values in a range of 3.45-9.03 μM, while excoecariphenol D and corilagin inhibited HCV RNA in huh 7.5 cells significantly. A primary structure-activity relationship (SAR) is discussed.

KW - Excoecaria agallocha L.

KW - Excoecariphenols A-D

KW - HCV RNA inhibition

KW - Huh 7.5 cells

KW - Mangrove plant

KW - NS3-4A protein kinase inhibition

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000299653500067

UR - https://openalex.org/W2137085874

UR - https://www.scopus.com/pages/publications/84855675976

U2 - 10.1016/j.bmcl.2011.11.109

DO - 10.1016/j.bmcl.2011.11.109

M3 - Journal Article

SN - 0960-894X

VL - 22

SP - 1099

EP - 1102

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.

Abstract

Keywords

UN SDGs

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