TY - JOUR
T1 - Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
AU - Li, Songshan
AU - He, Qinghai
AU - Wang, Hao
AU - Tang, Xuming
AU - Ho, Kam Wing
AU - Gao, Xin
AU - Zhang, Qian
AU - Shen, Yang
AU - Cheung, Annie
AU - Wong, Francis
AU - Wong, Yung Hou
AU - Ip, Nancy Y.
AU - Jiang, Liwen
AU - Yung, Wing Ho
AU - Liu, Kai
N1 - Publisher Copyright:
© 2014 Published by Elsevier Inc.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Despite advances in promoting axonal regeneration after adult central nervous system injury, elicitation of a large number of lesion-passing axons reform active synaptic connections with natural target neurons remains limited. By deleting both Pten and Socs3 in retinal ganglion cells, we report that optic nerve axons after prechiasm lesion robustly reinnervate the hypothalamus, form new synapses with neurons in the suprachiasmatic nucleus (SCN), and re-integrate with the existing circuitry. Photic or electric stimulation of the retinal axons induces neuronal response in SCN. However both the innervation pattern and evoked responses are not completely restored by the regenerating axons, suggesting that combining with other strategies is necessary to overcome the defective rewiring. Our results support that boosting the intrinsic growth capacity in injured neurons promotes axonal reinnervation and rewiring.
AB - Despite advances in promoting axonal regeneration after adult central nervous system injury, elicitation of a large number of lesion-passing axons reform active synaptic connections with natural target neurons remains limited. By deleting both Pten and Socs3 in retinal ganglion cells, we report that optic nerve axons after prechiasm lesion robustly reinnervate the hypothalamus, form new synapses with neurons in the suprachiasmatic nucleus (SCN), and re-integrate with the existing circuitry. Photic or electric stimulation of the retinal axons induces neuronal response in SCN. However both the innervation pattern and evoked responses are not completely restored by the regenerating axons, suggesting that combining with other strategies is necessary to overcome the defective rewiring. Our results support that boosting the intrinsic growth capacity in injured neurons promotes axonal reinnervation and rewiring.
KW - Axon regeneration and rewiring
KW - Intrinsic mechanisms
KW - Pre-chiasm lesion
KW - Retinal ganglion cells
KW - Suprachiasmatic nucleus
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000346328100034
UR - https://openalex.org/W1987306459
UR - https://www.scopus.com/pages/publications/84909960038
U2 - 10.1016/j.nbd.2014.09.019
DO - 10.1016/j.nbd.2014.09.019
M3 - Journal Article
C2 - 25448764
SN - 0969-9961
VL - 73
SP - 366
EP - 376
JO - Neurobiology of Disease
JF - Neurobiology of Disease
ER -