Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities

Yu Sheng Shi; Yan Zhang; Hao Tian Li; Chuan Hai Wu; Hesham R. El-Seedi; Wen Kang Ye; Zi Wei Wang; Chun Bin Li; Xu Fu Zhang; Guo Yin Kai

doi:10.1016/j.jff.2020.104213

Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities

Yu Sheng Shi, Yan Zhang, Hao Tian Li, Chuan Hai Wu, Hesham R. El-Seedi, Wen Kang Ye, Zi Wei Wang, Chun Bin Li, Xu Fu Zhang^*, Guo Yin Kai

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

102 Citations (Scopus)

Abstract

Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus. They are proved to be the leading cause of bitterness in Citrus fruits and are mainly consumed for therapeutic purposes and as food. Numerous studies have focused on Citrus limonoids and intend to develop new chemotherapeutic or complementary medicine in recent years. Citrus limonoids showed various bioactivities such as anti-tumor, antioxidative, anti-inflammatory, anti-neurological diseases, immunomodulatory, anti-insect, anti-bacteria, antiviral activities, etc. This review summarized limonoids from Citrus to date, along with their chemical structures and biological activities with a particular focus on their anti-tumor potential.

Original language	English
Article number	104213
Journal	Journal of Functional Foods
Volume	75
DOIs	https://doi.org/10.1016/j.jff.2020.104213
Publication status	Published - Dec 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020

Keywords

Anti-tumor
Bioactivity
Chemical structure
Citrus
Limonoid
Rutaceae

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10.1016/j.jff.2020.104213

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title = "Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities",

abstract = "Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus. They are proved to be the leading cause of bitterness in Citrus fruits and are mainly consumed for therapeutic purposes and as food. Numerous studies have focused on Citrus limonoids and intend to develop new chemotherapeutic or complementary medicine in recent years. Citrus limonoids showed various bioactivities such as anti-tumor, antioxidative, anti-inflammatory, anti-neurological diseases, immunomodulatory, anti-insect, anti-bacteria, antiviral activities, etc. This review summarized limonoids from Citrus to date, along with their chemical structures and biological activities with a particular focus on their anti-tumor potential.",

keywords = "Anti-tumor, Bioactivity, Chemical structure, Citrus, Limonoid, Rutaceae",

author = "Shi, \{Yu Sheng\} and Yan Zhang and Li, \{Hao Tian\} and Wu, \{Chuan Hai\} and El-Seedi, \{Hesham R.\} and Ye, \{Wen Kang\} and Wang, \{Zi Wei\} and Li, \{Chun Bin\} and Zhang, \{Xu Fu\} and Kai, \{Guo Yin\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = dec,

doi = "10.1016/j.jff.2020.104213",

language = "English",

volume = "75",

journal = "Journal of Functional Foods",

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T1 - Limonoids from Citrus

T2 - Chemistry, anti-tumor potential, and other bioactivities

AU - Shi, Yu Sheng

AU - Zhang, Yan

AU - Li, Hao Tian

AU - Wu, Chuan Hai

AU - El-Seedi, Hesham R.

AU - Ye, Wen Kang

AU - Wang, Zi Wei

AU - Li, Chun Bin

AU - Zhang, Xu Fu

AU - Kai, Guo Yin

PY - 2020/12

Y1 - 2020/12

N2 - Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus. They are proved to be the leading cause of bitterness in Citrus fruits and are mainly consumed for therapeutic purposes and as food. Numerous studies have focused on Citrus limonoids and intend to develop new chemotherapeutic or complementary medicine in recent years. Citrus limonoids showed various bioactivities such as anti-tumor, antioxidative, anti-inflammatory, anti-neurological diseases, immunomodulatory, anti-insect, anti-bacteria, antiviral activities, etc. This review summarized limonoids from Citrus to date, along with their chemical structures and biological activities with a particular focus on their anti-tumor potential.

AB - Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus. They are proved to be the leading cause of bitterness in Citrus fruits and are mainly consumed for therapeutic purposes and as food. Numerous studies have focused on Citrus limonoids and intend to develop new chemotherapeutic or complementary medicine in recent years. Citrus limonoids showed various bioactivities such as anti-tumor, antioxidative, anti-inflammatory, anti-neurological diseases, immunomodulatory, anti-insect, anti-bacteria, antiviral activities, etc. This review summarized limonoids from Citrus to date, along with their chemical structures and biological activities with a particular focus on their anti-tumor potential.

KW - Anti-tumor

KW - Bioactivity

KW - Chemical structure

KW - Citrus

KW - Limonoid

KW - Rutaceae

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UR - https://openalex.org/W3088151594

UR - https://www.scopus.com/pages/publications/85091371808

U2 - 10.1016/j.jff.2020.104213

DO - 10.1016/j.jff.2020.104213

M3 - Review article

SN - 1756-4646

VL - 75

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 104213

ER -

Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities

Abstract

Bibliographical note

Keywords

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