Loopholes in the DNA contract kill neurons

Karl Herrup; Kai Hei Tse; Hei Man Chow

doi:10.1038/nn.4626

Loopholes in the DNA contract kill neurons

Karl Herrup
, Kai Hei Tse
, Hei Man Chow

Division of Life Science

Research output: Contribution to journal › Short survey › peer-review

1 Citation (Scopus)

Abstract

Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA-RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.

Original language	English
Pages (from-to)	1192-1194
Number of pages	3
Journal	Nature Neuroscience
Volume	20
Issue number	9
DOIs	https://doi.org/10.1038/nn.4626
Publication status	Published - 1 Sept 2017

Access to Document

10.1038/nn.4626

Cite this

@article{6b0bf1f6b03f46e490cd8daf104ee0c4,

title = "Loopholes in the DNA contract kill neurons",

abstract = "Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA-RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.",

author = "Karl Herrup and Tse, \{Kai Hei\} and Chow, \{Hei Man\}",

year = "2017",

month = sep,

day = "1",

doi = "10.1038/nn.4626",

language = "English",

volume = "20",

pages = "1192--1194",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "9",

}

TY - JOUR

T1 - Loopholes in the DNA contract kill neurons

AU - Herrup, Karl

AU - Tse, Kai Hei

AU - Chow, Hei Man

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA-RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.

AB - Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA-RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000408587700002

UR - https://openalex.org/W2753763470

U2 - 10.1038/nn.4626

DO - 10.1038/nn.4626

M3 - Short survey

SN - 1097-6256

VL - 20

SP - 1192

EP - 1194

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 9

ER -

Loopholes in the DNA contract kill neurons

Abstract

Access to Document

Other files and links

Fingerprint

Cite this