Abstract
Proper organ development requires the precise regulation of both the total number of cells (cell proliferation) and the types of cells (cell differentiation). During cell proliferation, Cdt1 mediated loading of DNA helicase (Mcm2-7) to replication origins is required for DNA replication. And Hox gene activation is necessary for embryonic cell differentiation. It has been shown that these two processes are linked through the cell cycle-regulator Geminin and the homeodomain-containing transcription factors Hox. To understand the molecular mechanism involved, we determined the solution structures of Geminin-Hox, Orc6-DNA, G-quadruplex and Cdt1-Mcm6 complexes by nuclear magnetic resonance (NMR) spectroscopy and conducted biochemical study to delineate the structural basis of this mutual regulation. In addition, we found that histone H4-K20 methyltransferase SET8 is a new cell-cycle regulator and plays an important role in the developmental program of metazoans. (These works are supported by RGC, NSFC, and AoE/M-06/08)
| Original language | English |
|---|---|
| Publication status | Published - 2015 |
| Event | World congress on Cancer and Prevention Methods - Duration: 1 Jan 2015 → 1 Jan 2015 |
Conference
| Conference | World congress on Cancer and Prevention Methods |
|---|---|
| Period | 1/01/15 → 1/01/15 |
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