Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

Wenkui Dai; Hui Du; Qian Zhou; Sumei Li; Yinan Wang; Jun Hou; Chunlei Guo; Qing Yang; Changzhong Li; Shouxia Xie; Shuai Cheng Li; Ruifang Wu

doi:10.1038/s41522-024-00500-0

Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

Wenkui Dai, Hui Du, Qian Zhou, Sumei Li, Yinan Wang, Jun Hou, Chunlei Guo, Qing Yang, Changzhong Li, Shouxia Xie, Shuai Cheng Li^*, Ruifang Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

4 Citations (Scopus)

Abstract

There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.

Original language	English
Article number	26
Journal	npj Biofilms and Microbiomes
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41522-024-00500-0
Publication status	Published - Dec 2024
Externally published	Yes

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© The Author(s) 2024.

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title = "Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection",

abstract = "There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.",

author = "Wenkui Dai and Hui Du and Qian Zhou and Sumei Li and Yinan Wang and Jun Hou and Chunlei Guo and Qing Yang and Changzhong Li and Shouxia Xie and Li, \{Shuai Cheng\} and Ruifang Wu",

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doi = "10.1038/s41522-024-00500-0",

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T1 - Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

AU - Dai, Wenkui

AU - Du, Hui

AU - Zhou, Qian

AU - Li, Sumei

AU - Wang, Yinan

AU - Hou, Jun

AU - Guo, Chunlei

AU - Yang, Qing

AU - Li, Changzhong

AU - Xie, Shouxia

AU - Li, Shuai Cheng

AU - Wu, Ruifang

PY - 2024/12

Y1 - 2024/12

N2 - There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.

AB - There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001188129200001

UR - https://openalex.org/W4393004439

UR - https://www.scopus.com/pages/publications/85188161827

U2 - 10.1038/s41522-024-00500-0

DO - 10.1038/s41522-024-00500-0

M3 - Journal Article

SN - 2055-5008

VL - 10

JO - npj Biofilms and Microbiomes

JF - npj Biofilms and Microbiomes

IS - 1

M1 - 26

ER -

Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

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