@inproceedings{b879c53cdca5467f85c288bd62450339,
title = "Microfluidic flow reactors with integrated micro-heaters and fluorescent temperature sensors for reaction monitoring",
abstract = "We present the combined integration of fluorescent temperature sensor layers and resistive micro-heaters in microfluidic reactor chips and their application for temperature control and monitoring during an on-chip enzymatic conversion. The production process of the chips consists of wet chemical etching, photolithography, blade coating and soft lithography. These multifunctional chips allow both temperature control and microscopic imaging of the local temperature in microfluidic flow reactors. They are thus able to determine the temperature dependency of chemical and biological reaction on the microscale. This is demonstrated by the tryptic cleavage of modified peptides yielding a fluorescent product at different temperatures.",
keywords = "Enzymatic reaction, Flow reactor, Fluorescent temperature sensor, Microheater, Microscopic temperature control",
author = "Christian H{\"o}ra and Zhe Shu and Erik Beckert and Stefan Nagl and Detlev Belder",
year = "2013",
language = "English",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "784--786",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}